Signal transduction in human endothelial cells induced by their interaction with group B Streptococci

  • Authors:
    • Gabriela S. Santos
    • Viviane O.F. Lione
    • Fernando Costa E Silva Filho
    • Prescilla E. Nagao
  • View Affiliations

  • Published online on: May 1, 2005     https://doi.org/10.3892/ijmm.15.5.859
  • Pages: 859-863
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Abstract

The molecular mechanisms underlying entry of group B Streptococci (GBS) into human endothelial cells are not yet fully understood. This study is centered on the triggering of signaling cascade in human umbilical vein endothelial cells (HUVEC) during their interaction with different GBS serotypes/strains (type III: 80340-vagina and 90356-CSF and type V: 88641-vagina and 90186-blood). We have shown that the analyzed microorganisms adhere to HUVEC, but only those of the strains 90356-CSF, 88641-vagina and 90186-blood presented intracellular viability. Activation of PKC directly increased F-actin content and organization into stress fibers, and increased intracellular viability of GBS-III microorganisms. PKA inhibitor seems to promote surveillance of GBS type V microorganisms within HUVEC. These studies indicate that different molecules present at the cell surface of the GBS might induce different responses to HUVEC, interfering with the recruitment of cortical actin filaments.

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May 2005
Volume 15 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Santos GS, Lione VO, Costa E Silva Filho F and Nagao PE: Signal transduction in human endothelial cells induced by their interaction with group B Streptococci. Int J Mol Med 15: 859-863, 2005.
APA
Santos, G.S., Lione, V.O., Costa E Silva Filho, F., & Nagao, P.E. (2005). Signal transduction in human endothelial cells induced by their interaction with group B Streptococci. International Journal of Molecular Medicine, 15, 859-863. https://doi.org/10.3892/ijmm.15.5.859
MLA
Santos, G. S., Lione, V. O., Costa E Silva Filho, F., Nagao, P. E."Signal transduction in human endothelial cells induced by their interaction with group B Streptococci". International Journal of Molecular Medicine 15.5 (2005): 859-863.
Chicago
Santos, G. S., Lione, V. O., Costa E Silva Filho, F., Nagao, P. E."Signal transduction in human endothelial cells induced by their interaction with group B Streptococci". International Journal of Molecular Medicine 15, no. 5 (2005): 859-863. https://doi.org/10.3892/ijmm.15.5.859