Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues

  • Authors:
    • Yasuhiro Ito
    • Hiroshi Yoshida
    • Keiichi Nakano
    • Kaoru Kobayashi
    • Tamotsu Yokozawa
    • Keisuke Hirai
    • Fumio Matsuzuka
    • Nariaki Matsuura
    • Kanji Kuma
    • Akira Miyauchi
  • View Affiliations

  • Published online on: Monday, April 1, 2002
  • Pages: 373-376 DOI: 10.3892/ijmm.9.4.373

Abstract

p57 (Kip2) belongs to the Cip/Kip family and is one of the universal negative regulators of the cell cycle. In this study, we investigated the p57 expression of various types of thyroid neoplasm. p57 overexpression was observed in only 4.2% of normal thyroid tissues. In follicular adenoma and minimally invasive follicular carcinoma, p57 was overexpressed in 100% and 91.7% of the cases, respectively. However, its incidence was significantly lower (p<0.0001) in widely invasive follicular carcinoma, of which only 36.4% overexpressed p57. This phenomenon was seen in 63.1% of papillary carcinoma and 13.3% of anaplastic (undifferentiated) carcinoma. Furthermore, poorly differentiated and undifferentiated carcinoma more frequently lacked p57 expression (p<0.0001). These results suggest that the down-regulation of p57 may play a role in the dedifferentiation of thyroid carcinoma and in follicular carcinoma mutating to be more invasive.
Journal Cover

April 2002
Volume 9 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2014 Impact Factor: 2.088
Ranked #22/123 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Ito, Y., Yoshida, H., Nakano, K., Kobayashi, K., Yokozawa, T., Hirai, K. ... Miyauchi, A. (2002). Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues. International Journal of Molecular Medicine, 9, 373-376. http://dx.doi.org/10.3892/ijmm.9.4.373
MLA
Ito, Y., Yoshida, H., Nakano, K., Kobayashi, K., Yokozawa, T., Hirai, K., Matsuzuka, F., Matsuura, N., Kuma, K., Miyauchi, A."Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues". International Journal of Molecular Medicine 9.4 (2002): 373-376.
Chicago
Ito, Y., Yoshida, H., Nakano, K., Kobayashi, K., Yokozawa, T., Hirai, K., Matsuzuka, F., Matsuura, N., Kuma, K., Miyauchi, A."Expression of p57/Kip2 protein in normal and neoplastic thyroid tissues". International Journal of Molecular Medicine 9, no. 4 (2002): 373-376. http://dx.doi.org/10.3892/ijmm.9.4.373