The NGFI-B subfamily of the nuclear receptor superfamily (review).

  • Authors:
    • K Maruyama
    • T Tsukada
    • N Ohkura
    • S Bandoh
    • T Hosono
    • K Yamaguchi
  • Corresponding author:
  • View Affiliations

  • Published online on: Monday, June 1, 1998
  • Pages: 1237-1280
  • DOI: 10.3892/ijo.12.6.1237

Abstract

NGFI-B, Nurr1 and NOR-1 have structural features of ligand-activated transcriptional regulators and constitute the NGFI-B subfamily within the nuclear receptor superfamily. Since specific ligands for these molecules have not yet been identified, they are often called orphan nuclear receptors. Genes of the NGFI-B subfamily are classified as immediate-early genes that are induced rapidly but transiently by a variety of stimuli. Evidence accumulated over the past decade suggests this subfamily is involved in important physiological processes and cancer development. In this communication, we summarize and discuss their structural features, gene expression, physiological roles and oncological significance.
Journal Cover

June 1998
Volume 12 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Maruyama, K., Tsukada, T., Ohkura, N., Bandoh, S., Hosono, T., & Yamaguchi, K. (1998). The NGFI-B subfamily of the nuclear receptor superfamily (review).. International Journal of Oncology, 12, 1237-1280. http://dx.doi.org/10.3892/ijo.12.6.1237
MLA
Maruyama, K., Tsukada, T., Ohkura, N., Bandoh, S., Hosono, T., Yamaguchi, K."The NGFI-B subfamily of the nuclear receptor superfamily (review).". International Journal of Oncology 12.6 (1998): 1237-1280.
Chicago
Maruyama, K., Tsukada, T., Ohkura, N., Bandoh, S., Hosono, T., Yamaguchi, K."The NGFI-B subfamily of the nuclear receptor superfamily (review).". International Journal of Oncology 12, no. 6 (1998): 1237-1280. http://dx.doi.org/10.3892/ijo.12.6.1237