A MODEL ON THE ORIGIN AND EVOLUTION OF DNA ANEUPLOIDY
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- Published online on: February 1, 1993 https://doi.org/10.3892/ijo.2.2.165
- Pages: 165-171
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Abstract
A model on the origin and evolution of DNA aneuploidy based on a postulated mechanism of DNA asymmetrical cell division is presented. Asymmetry in cell division would be at the origin of hypodiploid cells in the near-diploid region. Tetraploidization of a hypodiploid cell would be one of the main routes by which advanced tumors may evolve to aneuploidy in the near-triploid region. The model is supported by nuclear DNA content data obtained by high resolution flow cytometry from fresh/frozen material during the colorectal tumor progression.