Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: Correlation with long-term patient outcome

  • Authors:
    • Jean-Philippe Dales
    • Stephane Garcia
    • Lucile Andrac
    • Severine Carpentier
    • Olivier Ramuz
    • Marie-Noëlle Lavaut
    • Claude Allasia
    • Pascal Bonnier
    • Colette Charpin
  • Corresponding author:
  • View Affiliations

  • Published online on: Saturday, May 1, 2004
  • Pages: 1197-1204 DOI: 10.3892/ijo.24.5.1197

Abstract

Our purpose was to determine the respective prognostic significance of CD105 and CD31 immunoexpression in node negative patients with breast carcinoma, since angiogenesis induces blood borne metastases and death in carcinomas. CD105 (endoglin) has been reported as expressed by activated endothelial cells and consequently should better reflect neoangiogenesis in malignant tumors. Comparison of CD31 and CD105 immunocytochemical expression was undertaken in a series of 905 breast carcinomas. Results were compared to patients' long-term (median = 11.3 years) outcome. Univariate (Kaplan-Meier) analysis showed that the number of CD105+ microvessels (cut-off 15 vessels) correlated significantly with poor overall survival (p=0.001). This correlation was less significant in node negative patients (p=0.035). The number of CD31+ microvessels (cut-off 25 vessels) similarly correlated with poor survival (p=0.032) but not in the subgroup of node negative patients. Marked CD105 expression also correlated with a high risk for metastasis in all patients (p=0.0002) and in the subset of node negative patients (p=0.001). Similarly metastasis risk in node negative patients correlated with marked CD31 immunocytochemical expression (p=0.02). Multivariate analysis (Cox model) identified CD105, but not CD31 immunoexpression, as an independent prognostic indicator. Our results suggest that: i) in breast carcinomas, immunoselection of microvessels containing activated CD105 labelled endothelial cells is endowed with a stronger prognostic significance, as compared to CD31 vessels labelling; ii) the CD105 immunoexpression may be considered as a potential tool for selecting node negative patients with a poorer outcome and higher metastasis risk; iii) in these patients specific antiangiogenic therapy targeted by anti-CD105 conjugates can be further developed.
Journal Cover

May 2004
Volume 24 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2014 Impact Factor: 3.025
Ranked #30/211 Oncology
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APA
Dales, J., Garcia, S., Andrac, L., Carpentier, S., Ramuz, O., Lavaut, M. ... Charpin, C. (2004). Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: Correlation with long-term patient outcome. International Journal of Oncology, 24, 1197-1204. http://dx.doi.org/10.3892/ijo.24.5.1197
MLA
Dales, J., Garcia, S., Andrac, L., Carpentier, S., Ramuz, O., Lavaut, M., Allasia, C., Bonnier, P., Charpin, C."Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: Correlation with long-term patient outcome". International Journal of Oncology 24.5 (2004): 1197-1204.
Chicago
Dales, J., Garcia, S., Andrac, L., Carpentier, S., Ramuz, O., Lavaut, M., Allasia, C., Bonnier, P., Charpin, C."Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: Correlation with long-term patient outcome". International Journal of Oncology 24, no. 5 (2004): 1197-1204. http://dx.doi.org/10.3892/ijo.24.5.1197