Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles

Yoshida,Tetsuro; Kato,Kimihiko; Oguri,Mitsutoshi; Horibe,Hideki; Kawamiya,Toshiki; Yokoi,Kiyoshi; Fujimaki,Tetsuo; Watanabe,Sachiro; Satoh,Kei; Aoyagi,Yukitoshi; Tanaka,Masashi; Yoshida,Hiroto; Shinkai,Shoji; Nozawa,Yoshinori; Yamada,Yoshiji

doi:10.3892/mmr.2011.441

Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles

Authors:
- Tetsuro Yoshida
- Kimihiko Kato
- Mitsutoshi Oguri
- Hideki Horibe
- Toshiki Kawamiya
- Kiyoshi Yokoi
- Tetsuo Fujimaki
- Sachiro Watanabe
- Kei Satoh
- Yukitoshi Aoyagi
- Masashi Tanaka
- Hiroto Yoshida
- Shoji Shinkai
- Yoshinori Nozawa
- Yoshiji Yamada
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Affiliations: Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan, Meitoh Hospital, Nagoya and Life Science Research Center, Mie University, Tsu, Mie, Japan, Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan, Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan, Department of Cardiology, Gifu Prefectural General Medical Center, Gifu, Japan, Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan, Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, Department of Genomics for Longevity and Health, Health Promotion, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, Gifu International Institute of Biotechnology and Tokai Gakuin University, Kakamigahara, Japan, Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
Published online on: February 18, 2011 https://doi.org/10.3892/mmr.2011.441
Pages: 511-518

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Abstract

Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We also showed that rs6929846 of BTN2A1 and rs2569512 of ILF3 were significantly associated with MI in Japanese individuals. In the present study, we examined the relationship between rs6929846 of BTN2A1 or rs2569512 of ILF3 and MI in individuals with low or high serum concentrations of triglycerides, high density lipoprotein (HDL) cholesterol, or low density lipoprotein (LDL) cholesterol, respectively. The study population comprised 5513 unrelated Japanese individuals, including 1537 subjects with MI and 3976 controls. Multivariable logistic regression analyses with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with MI in individuals with low (P=3.1x10-5; odds ratio, OR=1.66) or high (P=1.1x10-6; OR=2.09) triglycerides; in individuals with low (P=0.0082; OR=1.75) or high (P=2.0x10-9; OR=1.85) HDL cholesterol; and in individuals with low (P=3.2x10-7; OR=1.75) or high (P=2.8x10-5; OR=2.18) LDL cholesterol. Similar analyses revealed that rs2569512 of ILF3 was significantly associated with MI in individuals with low (P=0.0066; OR=1.47) or high (P=0.0013; OR=1.88) triglycerides; in individuals with low (P=0.0059; OR=1.96) or high (P=0.0020; OR=1.51) HDL cholesterol; and in individuals with low (P=0.0004, OR=1.62) LDL cholesterol, but not in those with high LDL cholesterol. The results suggest that the relationship between rs6929846 of BTN2A1 or rs2569512 of ILF3 and MI is influenced by the serum concentrations of HDL and LDL cholesterol, respectively. Stratification of subjects according to lipid profiles may thus be useful for the personalized prevention of MI based on genetic information.