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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2011 Volume 4 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2011 Volume 4 Issue 4

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Article

Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive protein in human lung epithelial cells

  • Authors:
    • Xi-Qian Xing
    • Shu Duan
    • Xu-Wei Wu
    • Ye Gan
    • Shui-Ping Zhao
    • Ping Chen
    • Shang-Jie Wu

  • View Affiliations / Copyright

    Affiliations: First Department of Respiratory Medicine, Yan'An Hospital Affilliated to Kunming Medical College, Yunnan 650051, P.R. China, Department of Respiratory Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Respiratory Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
  • Pages: 753-757
    |
    Published online on: May 16, 2011
       https://doi.org/10.3892/mmr.2011.491
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Abstract

Accumulating evidence suggests that statins possess anti-inflammatory properties and may decrease C-reactive protein (CRP) levels in plasma. However, no studies have as yet addressed whether or not statins regulate the expression of CRP in human lung epithelial cells (A549). In this study, we determined whether atorvastatin modulates the lipopolysaccharide (LPS)-induced expression of CRP in A549 cells. A549 cells were incubated in Dulbecco's modified Eagle's medium containing LPS in the absence or presence of various concentrations of atorvastatin. After incubation, the medium was collected and the amount of CRP was measured by an enzyme-linked immunosorbent assay. The cells were harvested and CRP messenger ribonucleic acid (mRNA) was analyzed by reverse transcription polymerase chain reaction. Incubation with LPS induced a significant time- and dose-dependent increase in CRP mRNA expression and CRP production in A549 cells, whereas atorvastatin significantly decreased LPS-induced CRP mRNA expression and CRP production in a dose-dependent manner. The present study revealed that A549 cells are capable of LPS-induced CRP expression, and that atorvastatin down-regulates the LPS-induced expression of CRP in cultured A549 cells. Our results suggest that statins ameliorate lung inflammation by regulating CRP production in human lung epithelial cells.

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Copy and paste a formatted citation
Spandidos Publications style
Xing X, Duan S, Wu X, Gan Y, Zhao S, Chen P and Wu S: Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive protein in human lung epithelial cells. Mol Med Rep 4: 753-757, 2011.
APA
Xing, X., Duan, S., Wu, X., Gan, Y., Zhao, S., Chen, P., & Wu, S. (2011). Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive protein in human lung epithelial cells. Molecular Medicine Reports, 4, 753-757. https://doi.org/10.3892/mmr.2011.491
MLA
Xing, X., Duan, S., Wu, X., Gan, Y., Zhao, S., Chen, P., Wu, S."Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive protein in human lung epithelial cells". Molecular Medicine Reports 4.4 (2011): 753-757.
Chicago
Xing, X., Duan, S., Wu, X., Gan, Y., Zhao, S., Chen, P., Wu, S."Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive protein in human lung epithelial cells". Molecular Medicine Reports 4, no. 4 (2011): 753-757. https://doi.org/10.3892/mmr.2011.491
Copy and paste a formatted citation
x
Spandidos Publications style
Xing X, Duan S, Wu X, Gan Y, Zhao S, Chen P and Wu S: Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive protein in human lung epithelial cells. Mol Med Rep 4: 753-757, 2011.
APA
Xing, X., Duan, S., Wu, X., Gan, Y., Zhao, S., Chen, P., & Wu, S. (2011). Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive protein in human lung epithelial cells. Molecular Medicine Reports, 4, 753-757. https://doi.org/10.3892/mmr.2011.491
MLA
Xing, X., Duan, S., Wu, X., Gan, Y., Zhao, S., Chen, P., Wu, S."Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive protein in human lung epithelial cells". Molecular Medicine Reports 4.4 (2011): 753-757.
Chicago
Xing, X., Duan, S., Wu, X., Gan, Y., Zhao, S., Chen, P., Wu, S."Atorvastatin reduces lipopolysaccharide-induced expression of C-reactive protein in human lung epithelial cells". Molecular Medicine Reports 4, no. 4 (2011): 753-757. https://doi.org/10.3892/mmr.2011.491
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