|Investigation of the correlation between norepinephrine transporter gene polymorphisms and essential hypertension|
Authors: Ying Li, Liqiang Zheng, Dingyin Zeng, Ying Hao, Baogang Wu, Yingxian Sun
Affiliations: Department of Cardiac Diseases, the First Affiliated Hospital of China Medical University, Shen Yang, Liao Ning 110001, P.R. China, Sheng Jing Hospital of China Medical University, Shen Yang, Liao Ning 110004, P.R. China, Jin Qiu Hospital of Liaoning Province, Shen Yang, Liaoning 110015, P.R. China
Published online on: Thursday, October 18, 2012
Essential hypertension (EH) is an etiological risk factor that poses a serious threat to human health. The aim of this study therefore was to investigate the correlation between the two SNPs (rs1805067 and rs2397771) of the norepinephrine (NE) transporter gene in the sympathetic nervous system and essential hypertension (EH). A total of 96 hypertensive patients (EH group) and 96 normal subjects (control group) were selected by epidemiological investigation and the sequences at rs1805067 and rs2397771 in the two groups were investigated using polymerase chain reaction (PCR) and Sanger sequencing. In the EH group, systolic and diastolic blood pressure, body mass index (BMI), levels of creatinine, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and the percentage of drinkers were found to be higher compared with those of the control group (P<0.05). The results of the analysis of the allele frequencies of rs1805067 (A/G) revealed that there was no difference between the two groups (P>0.05). The analysis results of the allele frequencies of rs2397771 (C/G) in the EH group revealed that G accounted for 48.96% and C for 51.04% of the patients, while in the control group, these values were 64.58 and 35.42%, respectively. These results indicated a significant difference between the two groups (P<0.05). In the population studied, the onset of EH may be correlated with BMI, TG, LDL-C and high-density lipoprotein cholesterol (HDL-C). EH may be related to the rs2397771 (C/G) C allele polymorphism of the NE transporter gene but not to rs1805067 (A/G).