Bif-1 is overexpressed in hepatocellular carcinoma and correlates with shortened patient survival

  • Authors: Rengen Fan, Yufeng Miao, Xiangxiang Shan, Haixin Qian, Changzhi Song, Guangzhou Wu, Yan Chen, Wenzhang Zha
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  • Published online on: Thursday, January 12, 2012
  • Pages: 851-854
  • DOI: 10.3892/ol.2012.562


Bax-interacting factor-1 (Bif-1) interacts with Beclin1 [the mammalian ortholog of yeast autophagy‑related gene 6 (Atg6)] and affects the formation of autophagosomes during autophagy. The aim of this study was to explore Bif-1 expression and its prognostic significance in comparison with various clinicopathological predictors of survival. Bif-1 protein expression was determined by immunohistochemistry in 206 hepatocellular carcinomas. Cytoplasmic immunoreactivity was scored semi-quantitatively. The results were analyzed in correlation with various clinicopathological characteristics, including patient survival. The Chi-square test and Kaplan-Meier survival analysis were applied. The expression of Bif-1 was significantly higher in the hepatocellular cancers than in the adjacent matched non‑tumor tissues (51.5 vs. 33.0%, P<0.01). Increased expression of Bif-1 in hepatocellular carcinomas was significantly correlated with a low grade of differentiation and a shortened overall survival (P<0.05). No significant differences were found between the expression of Bif-1 and age, gender, tumor size, damage of capsule, expression of hepatitis B surface antigen (HBs-Ag) and portal venous invasion. Our data demonstrated that Bif-1 is frequently expressed in hepatocellular carcinoma. Overexpression of Bif-1 is a new independent prognostic marker, which is associated with poor differentiation as well as shortened overall survival.
Journal Cover

April 2012
Volume 3 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

2013 Impact Factor: 0.987
Ranked #149/202 Oncology
(total number of cites)

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