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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2005 Volume 14 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Recurrence and 5-FU sensitivity of stage III/Dukes' C colorectal cancer with occult neoplastic cells in lymph node sinuses

  • Authors:
    • Masaya Mukai
    • Shinkichi Sato
    • Hiromi Ninomiya
    • Kanako Wakui
    • Nobukazu Komatsu
    • Kazutoshi Tsuchiya
    • Hisao Nakasaki
    • Hiroyasu Makuuchi

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University Hachioji Hospital, Ishikawa-cho, Hachioji, Tokyo 192-0032, Japan. mukai.masaya@hachioji-hosp.tokai.ac.jp
  • Pages: 1165-1169
    |
    Published online on: November 1, 2005
       https://doi.org/10.3892/or.14.5.1165
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Abstract

In 72 patients without occult neoplastic cells (ONCs) in their lymph node sinuses, the 5-year relapse-free survival (RFS) rate and overall survival (OS) rate were 71.3% and 69.2%, respectively. In 33 patients with ONCs, the 5-year RFS rate and OS rate were 33.9% and 31.3%, respectively. There was a marked difference of survival between the two groups (p=0.0001 and p=0.0003). The metastatic lymph nodes of the 33 ONC-positive patients had high and low levels of thymidilate synthase (TS) expression in 38.1% (8/21) and 61.9% (13/21) of the recurrence group (n=21), respectively, while high and low levels of dihydropyrimidine dehydrogenase (DPD) expression were found in 38.1% (8/21) and 61.9% (13/21), respectively. In the non-recurrence group (n=12), high and low levels of TS or DPD expression were detected in 58.3% (7/12) and 41.7% (5/12) versus 16.7% (2/12) and 83.3% (10/12), respectively. Patients with high TS and low DPD expression accounted for 9.5% (2/21) of the recurrence group and 50.0% (6/12) of the non-recurrence group (p<0.01). These results suggest that ONCs are clearly associated with the 5-year RFS and OS rates. Unlike the non-recurrence group, the recurrence group of ONC-positive patients with Dukes' C colorectal cancer is unlikely to respond well to treatment with 5-FU plus LV and require combination chemotherapy based on CPT-11 and/or L-OHP.

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Copy and paste a formatted citation
Spandidos Publications style
Mukai M, Sato S, Ninomiya H, Wakui K, Komatsu N, Tsuchiya K, Nakasaki H and Makuuchi H: Recurrence and 5-FU sensitivity of stage III/Dukes' C colorectal cancer with occult neoplastic cells in lymph node sinuses. Oncol Rep 14: 1165-1169, 2005.
APA
Mukai, M., Sato, S., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K. ... Makuuchi, H. (2005). Recurrence and 5-FU sensitivity of stage III/Dukes' C colorectal cancer with occult neoplastic cells in lymph node sinuses. Oncology Reports, 14, 1165-1169. https://doi.org/10.3892/or.14.5.1165
MLA
Mukai, M., Sato, S., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage III/Dukes' C colorectal cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 14.5 (2005): 1165-1169.
Chicago
Mukai, M., Sato, S., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage III/Dukes' C colorectal cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 14, no. 5 (2005): 1165-1169. https://doi.org/10.3892/or.14.5.1165
Copy and paste a formatted citation
x
Spandidos Publications style
Mukai M, Sato S, Ninomiya H, Wakui K, Komatsu N, Tsuchiya K, Nakasaki H and Makuuchi H: Recurrence and 5-FU sensitivity of stage III/Dukes' C colorectal cancer with occult neoplastic cells in lymph node sinuses. Oncol Rep 14: 1165-1169, 2005.
APA
Mukai, M., Sato, S., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K. ... Makuuchi, H. (2005). Recurrence and 5-FU sensitivity of stage III/Dukes' C colorectal cancer with occult neoplastic cells in lymph node sinuses. Oncology Reports, 14, 1165-1169. https://doi.org/10.3892/or.14.5.1165
MLA
Mukai, M., Sato, S., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage III/Dukes' C colorectal cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 14.5 (2005): 1165-1169.
Chicago
Mukai, M., Sato, S., Ninomiya, H., Wakui, K., Komatsu, N., Tsuchiya, K., Nakasaki, H., Makuuchi, H."Recurrence and 5-FU sensitivity of stage III/Dukes' C colorectal cancer with occult neoplastic cells in lymph node sinuses". Oncology Reports 14, no. 5 (2005): 1165-1169. https://doi.org/10.3892/or.14.5.1165
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