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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2006 Volume 15 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases

  • Authors:
    • Seiichi Shinji
    • Zenya Naito
    • Shunji Ishiwata
    • Toshiyuki Ishiwata
    • Noritake Tanaka
    • Kiyonori Furukawa
    • Hideyuki Suzuki
    • Tomoko Seya
    • Akihisa Matsuda
    • Miwako Katsuta
    • Takashi Tajiri

  • View Affiliations / Copyright

    Affiliations: Department of Surgery for Organ and Biological Regulation (Department of Surgery I), Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan
  • Pages: 539-543
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/or.15.3.539
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Abstract

Ubiquitin-specific protease 14, also known as the 60 kDa subunit of tRNA-guanine transglycosylase (USP14/TGT60kD), belongs to the ubiquitin-specific processing protease (UBP) family. USP14/TGT60kD expression in leukemic and colorectal cancer cell lines, and the suppression of such an expression after the induction of cell differentiation have been reported. In the present study, we attempted to clarify whether USP14/TGT60kD overexpression affects the clinicopathological features of colorectal cancer. Immunohistochemically, USP14/TGT60kD was absent or weakly localized in the cytoplasm of normal colorectal epithelial cells. In 18 of 99 (18.2%) colorectal cancer patients, USP14/TGT60kD was strongly detected in the cytoplasm of cancer cells. USP14/TGT60kD expression correlated with pathological stage (P=0.03), and lymph node (P=0.03) and liver (P=0.03) metastases. Furthermore, the percentage of patients strongly positive for USP14/TGT60kD expression increased with pathological stage. The overall survival rate was worse in patients with a high USP14/TGT60kD expression level than in those with a low USP14/TGT60kD expression level. Our results suggest that USP14/TGT60kD also controls the fate of proteins that regulate tumor invasion and metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Shinji S, Naito Z, Ishiwata S, Ishiwata T, Tanaka N, Furukawa K, Suzuki H, Seya T, Matsuda A, Katsuta M, Katsuta M, et al: Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. Oncol Rep 15: 539-543, 2006.
APA
Shinji, S., Naito, Z., Ishiwata, S., Ishiwata, T., Tanaka, N., Furukawa, K. ... Tajiri, T. (2006). Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. Oncology Reports, 15, 539-543. https://doi.org/10.3892/or.15.3.539
MLA
Shinji, S., Naito, Z., Ishiwata, S., Ishiwata, T., Tanaka, N., Furukawa, K., Suzuki, H., Seya, T., Matsuda, A., Katsuta, M., Tajiri, T."Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases". Oncology Reports 15.3 (2006): 539-543.
Chicago
Shinji, S., Naito, Z., Ishiwata, S., Ishiwata, T., Tanaka, N., Furukawa, K., Suzuki, H., Seya, T., Matsuda, A., Katsuta, M., Tajiri, T."Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases". Oncology Reports 15, no. 3 (2006): 539-543. https://doi.org/10.3892/or.15.3.539
Copy and paste a formatted citation
x
Spandidos Publications style
Shinji S, Naito Z, Ishiwata S, Ishiwata T, Tanaka N, Furukawa K, Suzuki H, Seya T, Matsuda A, Katsuta M, Katsuta M, et al: Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. Oncol Rep 15: 539-543, 2006.
APA
Shinji, S., Naito, Z., Ishiwata, S., Ishiwata, T., Tanaka, N., Furukawa, K. ... Tajiri, T. (2006). Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases. Oncology Reports, 15, 539-543. https://doi.org/10.3892/or.15.3.539
MLA
Shinji, S., Naito, Z., Ishiwata, S., Ishiwata, T., Tanaka, N., Furukawa, K., Suzuki, H., Seya, T., Matsuda, A., Katsuta, M., Tajiri, T."Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases". Oncology Reports 15.3 (2006): 539-543.
Chicago
Shinji, S., Naito, Z., Ishiwata, S., Ishiwata, T., Tanaka, N., Furukawa, K., Suzuki, H., Seya, T., Matsuda, A., Katsuta, M., Tajiri, T."Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases". Oncology Reports 15, no. 3 (2006): 539-543. https://doi.org/10.3892/or.15.3.539
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