Myeloid leukemia-1 expression in benign and malignant melanocytic lesions

  • Authors:
    • Ronald P.C. Wong
    • Shahram Khosravi
    • Magdalena Martinka
    • Gang Li
  • Corresponding author:
  • View Affiliations

  • Published online on: Tuesday, April 1, 2008
  • Pages: 933-937 DOI: 10.3892/or.19.4.933

Abstract

Myeloid leukemia-1 (Mcl-1) is an anti-apoptotic protein implicated in tumor progression. Its expression was found to be elevated in many types of human cancers and is correlated with tumor progression. The expression of Mcl-1 in melanoma is not fully understood. We investigated the expression of Mcl-1 in normal nevi, dysplastic nevi, primary melanoma and melanoma metastases by tissue microarray and immunohistochemistry. We found that Mcl-1 expression was significantly increased in dysplastic nevi, primary melanoma and melanoma metastases when compared to normal nevi, though the expression of Mcl-1 was decreased in metastatic melanoma when compared to dysplastic nevi. We did not find any correlation between Mcl-1 expression and melanoma patient survival. Our data suggest that Mcl-1 may play a critical role in the initiation of melanoma development.
Journal Cover

April 2008
Volume 19 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
2014 I.F. (Expected) ≥ 2.527 Ranked #33/202 Oncology
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APA
Wong, R.P., Khosravi, S., Martinka, M., & Li, G. (2008). Myeloid leukemia-1 expression in benign and malignant melanocytic lesions. Oncology Reports, 19, 933-937. http://dx.doi.org/10.3892/or.19.4.933
MLA
Wong, R. P., Khosravi, S., Martinka, M., Li, G."Myeloid leukemia-1 expression in benign and malignant melanocytic lesions". Oncology Reports 19.4 (2008): 933-937.
Chicago
Wong, R. P., Khosravi, S., Martinka, M., Li, G."Myeloid leukemia-1 expression in benign and malignant melanocytic lesions". Oncology Reports 19, no. 4 (2008): 933-937. http://dx.doi.org/10.3892/or.19.4.933