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Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma

  • Authors:
    • Chunnan Li
    • Satoru Shintani
    • Nagaaki Terakado
    • Koh-ichi Nakashiro
    • Hiroyuki Hamakawa

  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/or.9.6.1219
  • Pages: 1219-1223
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Tumor-associated macrophages (TAMs) have been shown to display both positive and negative effects on tumor growth of various cancer. In this study, TAMs were immunohistochemically labeled using CD68 antibody in 82 oral cancer. Macrophage index (MI) were analyzed in association with clinical and pathological factors, intratumoral microvessel density (IMVD) and angiogenic factors including VEGF and TP. Significantly higher number of CD68-positive cells was noted in oral cancer. TAM expressions were significantly associated with stages of invasion, IMVD, and angiogenic factors. These findings suggest that TAMs possibly play a role in angiogenesis during oral cancer progression.

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Journal Cover

November-December 2002
Volume 9 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Li C, Shintani S, Terakado N, Nakashiro K and Hamakawa H: Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma. Oncol Rep 9: 1219-1223, 2002
APA
Li, C., Shintani, S., Terakado, N., Nakashiro, K., & Hamakawa, H. (2002). Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma. Oncology Reports, 9, 1219-1223. https://doi.org/10.3892/or.9.6.1219
MLA
Li, C., Shintani, S., Terakado, N., Nakashiro, K., Hamakawa, H."Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma". Oncology Reports 9.6 (2002): 1219-1223.
Chicago
Li, C., Shintani, S., Terakado, N., Nakashiro, K., Hamakawa, H."Infiltration of tumor-associated macrophages in human oral squamous cell carcinoma". Oncology Reports 9, no. 6 (2002): 1219-1223. https://doi.org/10.3892/or.9.6.1219