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Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array

  • Authors:
    • Huakun Zhang
    • Haiqing Ma
    • Qijing Wang
    • Minshan Chen
    • Desheng Weng
    • Hui Wang
    • Jun Zhou
    • Yongqiang Li
    • Jiancong Sun
    • Yibing Chen
    • Xiaoting Liang
    • Jingjing Zhao
    • Ke Pan
    • Huiyun Wang
    • Jianchuan Xia

  • View Affiliations

  • Published online on: February 1, 2010     https://doi.org/10.3892/or_00000654
  • Pages: 445-455
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Abstract

To identify tumour suppressor genes (TSGs) associated with hepatocellular carcinoma (HCC) on chromosome 4q using a high-throughput single nucleotide polymorphism (SNP) array, we first scanned for loss of heterozygosity (LOH) of 40 SNPs on chromosome 4q and discovered 2 hot regions: 4q24-26 and 4q34.3-35. We then further scanned for LOH of 338 SNPs in genes around 4q34.3-35 and discovered 3 genes with the most frequent LOH: nei endonuclease VIII-like 3 (NEIL3), interferon regulatory factor 2 (IRF2) and inhibitor of growth family member 2 (ING2). A review of the literature indicates only ING2 might be a TSG associated with HCC.

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February 2010
Volume 23 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang H, Ma H, Wang Q, Chen M, Weng D, Wang H, Zhou J, Li Y, Sun J, Chen Y, Chen Y, et al: Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array. Oncol Rep 23: 445-455, 2010
APA
Zhang, H., Ma, H., Wang, Q., Chen, M., Weng, D., Wang, H. ... Xia, J. (2010). Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array. Oncology Reports, 23, 445-455. https://doi.org/10.3892/or_00000654
MLA
Zhang, H., Ma, H., Wang, Q., Chen, M., Weng, D., Wang, H., Zhou, J., Li, Y., Sun, J., Chen, Y., Liang, X., Zhao, J., Pan, K., Wang, H., Xia, J."Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array". Oncology Reports 23.2 (2010): 445-455.
Chicago
Zhang, H., Ma, H., Wang, Q., Chen, M., Weng, D., Wang, H., Zhou, J., Li, Y., Sun, J., Chen, Y., Liang, X., Zhao, J., Pan, K., Wang, H., Xia, J."Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array". Oncology Reports 23, no. 2 (2010): 445-455. https://doi.org/10.3892/or_00000654