Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

Lerner,Cornelia; Wemmert,Silke; Schick,Bernhard

doi:10.3892/br.2014.350

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

Authors:
- Cornelia Lerner
- Silke Wemmert
- Bernhard Schick
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Affiliations: Department of Otolaryngology, Saarland University Medical Center, D‑66421 Homburg/Saar, Germany
Published online on: August 19, 2014 https://doi.org/10.3892/br.2014.350
Pages: 835-838

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Abstract

Juvenile angiofibroma (JA) is a rare fibrovascular tumor affecting, almost exclusively, adolescent males. The finding of frequent β‑catenin‑mutations in JAs emphasized the significance of the Wnt‑signaling pathway in tumor pathogenesis. In the last decade, microRNAs (miRNAs or miRs) have been found to be involved in cancer pathogenesis by post‑transcriptional regulation of gene expression and have not been analyzed in JAs thus far. In the present study, the expression of 4 miRNAs (hsa‑let‑7d, hsa‑miR‑98, hsa‑miR‑125a‑5p and hsa‑miR‑218) was analyzed in 13 JAs and 3 deepithelized inferior nasal turbinates that were used as control tissue. The miRNA expression of hsa‑let‑7d (P=0.158) and hsa‑miR‑98 (P=0.069) was not statistically different between the two tissue types, however, a significant decrease in expression was observed for hsa‑miR‑125a‑5p (P=0.037) and hsa‑miR‑218 (P=0.009) in JAs compared to inferior nasal turbinates. As downregulation of miRNA 218 has been recently shown to result in stabilization and nuclear accumulation of β‑catenin, the present data indicates further evidence for the importance of the Wnt‑signaling pathway in JAs.

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