Association between fetuin‑A levels with insulin resistance and carotid intima‑media thickness in patients with new‑onset type 2 diabetes mellitus

Yin,Liang; Cai,Wei‑Juan; Chang,Xiang‑Yun; Li,Jun; Su,Xiang‑Hui; Zhu,Ling‑Yun; Wang,Xiao‑Li; Sun,Kan

doi:10.3892/br.2014.356

Association between fetuin‑A levels with insulin resistance and carotid intima‑media thickness in patients with new‑onset type 2 diabetes mellitus

Authors:
- Liang Yin
- Wei‑Juan Cai
- Xiang‑Yun Chang
- Jun Li
- Xiang‑Hui Su
- Ling‑Yun Zhu
- Xiao‑Li Wang
- Kan Sun
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Affiliations: Department of Endocrinology and Metabolism, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, P.R. China, Department of Clinical Laboratory, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, P.R. China
Published online on: September 5, 2014 https://doi.org/10.3892/br.2014.356
Pages: 839-842

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Abstract

Fetuin‑A, which is known to inhibit insulin signaling and pathological calcification, has emerged as a diabetes risk biomarker. In the present study, the association between the fetuin‑A levels with insulin resistance (IR) and carotid intima‑media thickness (CIMT) was investigated in patients with new‑onset type 2 diabetes mellitus (nT2DM). A total of 100 patients with nT2DM (nT2DM group) and 100 normal glucose tolerance (NGT group) controls were evaluated. The serum fetuin‑A level was measured by a commercial solid‑phase ELISA kit. The estimate of IR was calculated by homeostasis model assessment (HOMA‑IR). CIMT was measured by B‑mode ultrasound. The association between the serum fetuin‑A levels and the metabolic parameters was also analyzed. The serum fetuin‑A levels were increased significantly in the nT2DM group compared to the NGT group (368.5±15.6 mg/ml vs. 152.7±7.1 mg/ml, P<0.01). Fetuin‑A was positively correlated with HOMA‑IR, CIMT, glycated hemoglobin, triglyceride, low‑density lipoprotein cholesterol, body mass index, systolic blood pressure, fasting blood glucose and 2 h post‑glucose load blood glucose (P<0.05 and P<0.01), but negatively correlated with fasting plasma insulin, 2 h plasma insulin after glucose overload, high‑density lipoprotein cholesterol and HOMA‑β‑cell insulin secretion index (P<0.05 and P<0.01). To the best of our knowledge, the study demonstrated for the first time that there is a significant association between the serum fetuin‑A levels with IR and CIMT in nT2DM. These results indicate that serum fetuin‑A levels can be used as independent markers in the diagnosis of macroangiopathies in nT2DM.

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