MHC class I-related chain B gene polymorphism is associated with virological response to pegylated interferon plus ribavirin therapy in patients with chronic hepatitis C infection

  • Authors:
    • Ayumi Asada
    • Makoto Shioya
    • Rie Osaki
    • Takashi Nishimura
    • Takayuki Takeuchi
    • Yoshiaki Okumura
    • Akira Andoh
  • View Affiliations

  • Published online on: December 17, 2014     https://doi.org/10.3892/br.2014.406
  • Pages: 247-253
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Abstract

The outcome of antiviral therapy is associated with viral and host factors. In the present study, the association between MHC class I‑related chain B (MICB) genotypes and therapeutic response to pegylated interferon plus ribavirin (PEG‑IFN/RBV) therapy was investigated in hepatitis C virus (HCV)‑infected patients. In total, 107 patients with chronic HCV infection (74 with HCV serotype 1 and 33 with serotype 2) were enrolled. Genotyping of MICB single‑nucleotide polymorphism (SNP) rs3828913 and interleukin‑28B (IL28B) SNP rs8099917 was performed using TaqMan® SNP genotyping assays. The genotype distribution of the MICB alleles was: CC, 79.4%; CA, 17.8%; and AA, 2.8%. Sustained virological response (SVR) was achieved by 55.1% (59/107) of the HCV patients. The SVR rate of patients with MICB major (CC) alleles was 62.3% and this rate was significantly higher than that of the patients with MICB minor (CA and AA) alleles (27.2%) (P=0.0068). A multivariate logistic model showed that the MICB major genotype was an independent factor contributing to SVR (OR, 4.47; 95% CI, 1.46‑13.70; P=0.009). In addition, the MICB genotype was identified as the sole independent factor contributing to SVR and non‑virological response in HCV serotype 1 patients with the IL28B major genotype. In HCV serotype 2 patients, the MICB genotype was the sole significant factor contributing to SVR (OR, 30.68; 95% CI, 2.72‑346.3; P=0.006). In conclusion, the MICB genotype is a strong predictive factor for virological response to PEG‑IFN/RBV therapy in HCV patients.
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Spandidos Publications style
Asada A, Shioya M, Osaki R, Nishimura T, Takeuchi T, Okumura Y and Andoh A: MHC class I-related chain B gene polymorphism is associated with virological response to pegylated interferon plus ribavirin therapy in patients with chronic hepatitis C infection. Biomed Rep 3: 247-253, 2015
APA
Asada, A., Shioya, M., Osaki, R., Nishimura, T., Takeuchi, T., Okumura, Y., & Andoh, A. (2015). MHC class I-related chain B gene polymorphism is associated with virological response to pegylated interferon plus ribavirin therapy in patients with chronic hepatitis C infection. Biomedical Reports, 3, 247-253. https://doi.org/10.3892/br.2014.406
MLA
Asada, A., Shioya, M., Osaki, R., Nishimura, T., Takeuchi, T., Okumura, Y., Andoh, A."MHC class I-related chain B gene polymorphism is associated with virological response to pegylated interferon plus ribavirin therapy in patients with chronic hepatitis C infection". Biomedical Reports 3.2 (2015): 247-253.
Chicago
Asada, A., Shioya, M., Osaki, R., Nishimura, T., Takeuchi, T., Okumura, Y., Andoh, A."MHC class I-related chain B gene polymorphism is associated with virological response to pegylated interferon plus ribavirin therapy in patients with chronic hepatitis C infection". Biomedical Reports 3, no. 2 (2015): 247-253. https://doi.org/10.3892/br.2014.406