Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

Kumagai,Kenichi; Suzuki,Satsuki; Kanri,Yoriaki; Matsubara,Ryota; Fujii,Keisuke; Wake,Masahiro; Suzuki,Ryuji; Hamada,Yoshiki

doi:10.3892/br.2015.467

Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

Authors:
- Kenichi Kumagai
- Satsuki Suzuki
- Yoriaki Kanri
- Ryota Matsubara
- Keisuke Fujii
- Masahiro Wake
- Ryuji Suzuki
- Yoshiki Hamada
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Affiliations: Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Kanagawa 230‑8501, Japan, Section of Biological Science Research Center for Odontology, School of Dentistry, Nippon Dental University, Tokyo 102‑8159, Japan, Department of Pathology, School of Life Dentistry at Niigata, The Nippon Dental University, Niigata, Niigata 951‑8580, Japan, Department of Oral and Maxillofacial Surgery, Sagamihara Kyodo Hospital, Sagamihara, Kanagawa 252-0143, Japan, Department of Oral and Maxillofacial Surgery, Sendai Tokushukai Hospital, Sendai, Miyagi 981‑3131, Japan, Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Kanagawa 228‑0815, Japan
Published online on: May 21, 2015 https://doi.org/10.3892/br.2015.467
Pages: 453-456
Copyright: © Kumagai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Temporomandibular joint (TMJ) osteoarthritis is typically a slowly progressive asymmetric disease. Little is known regarding the natural destruction of TMJ articular tissues. The aim of the present study was to investigate morphological changes in the TMJ of STR/ort mice, known to be the model for spontaneous osteoarthritis in the knee joint, and to evaluate STR/ort mice as a suitable animal model for TMJ osteoarthritis. TMJs from 32 STR/ort mice euthanized at 30, 40, 50 or 60 weeks of age, and from 6 CBA mice euthanized at 30, 40 or 60 weeks of age were examined. Toluidine blue and tartrate‑resistant acid phosphatase staining were used to assess histological changes in the articular cartilage. Morphological changes in the articular cartilage of the TMJ were evaluated using microcomputed tomography. At the age of 40‑50 weeks, 17 (68%) of the 25 STR/ort mice had loss of articular cartilage on histology, with cavitation and erosion of the exposed bone and gradual changes in condylar shape. Furthermore, osteoarthritic morphological changes, and structural alterations were observed by microcomputed tomography. The STR/ort mouse strain appears to develop spontaneous osteoarthritis‑like lesions in the TMJ with age, and would be a useful model to study the pathogenesis of TMJ osteoarthritis.

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1	Shen G and Darendeliler MA: The adaptive remodeling of condylar cartilage - a transition from chondrogenesis to osteogenesis. J Dent Res. 84:691–699. 2005. View Article : Google Scholar : PubMed/NCBI
2	Chen WH, Hosokawa M, Tsuboyama T, Ono T, Iizuka T and Takeda T: Age-related changes in the temporomandibular joint of the senescence accelerated mouse. SAM-P/3 as a new murine model of degenerative joint disease. Am J Pathol. 135:379–385. 1989.PubMed/NCBI
3	Embree M, Ono M, Kilts T, Walker D, Langguth J, Mao J, Bi Y, Barth JL and Young M: Role of subchondral bone during early-stage experimental TMJ osteoarthritis. J Dent Res. 90:1331–1338. 2011. View Article : Google Scholar : PubMed/NCBI
4	Chambers MG, Cox L, Chong L, Suri N, Cover P, Bayliss MT and Mason RM: Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice. Arthritis Rheum. 44:1455–1465. 2001. View Article : Google Scholar : PubMed/NCBI
5	Mehraban F, Lark MW, Ahmed FN, Xu F and Moskowitz RW: Increased secretion and activity of matrix metalloproteinase-3 in synovial tissues and chondrocytes from experimental osteoarthritis. Osteoarthritis Cartilage. 6:286–294. 1998. View Article : Google Scholar : PubMed/NCBI
6	van de Loo FA, Joosten LA, van Lent PL, Arntz OJ and van den Berg WB: Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum. 38:164–172. 1995. View Article : Google Scholar : PubMed/NCBI
7	Kammermann JR, Kincaid SA, Rumph PF, Baird DK and Visco DM: Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: Immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage. Osteoarthritis Cartilage. 4:23–34. 1996. View Article : Google Scholar : PubMed/NCBI
8	Janusz MJ, Hookfin EB, Heitmeyer SA, Woessner JF, Freemont AJ, Hoyland JA, Brown KK, Hsieh LC, Almstead NG, De B, et al: Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors. Osteoarthritis Cartilage. 9:751–760. 2001. View Article : Google Scholar : PubMed/NCBI
9	Puzas JE, Landeau JM, Tallents R, Albright J, Schwarz EM and Landesberg R: Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activity. Cells Tissues Organs. 169:248–256. 2001. View Article : Google Scholar : PubMed/NCBI
10	Flannelly J, Chambers MG, Dudhia J, Hembry RM, Murphy G, Mason RM and Bayliss MT: Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. Osteoarthritis Cartilage. 10:722–733. 2002. View Article : Google Scholar : PubMed/NCBI
11	Blumenfeld I, Laufer D and Livne E: Effects of transforming growth factor-beta 1 and interleukin-1 alpha on matrix synthesis in osteoarthritic cartilage of the temporo-mandibular joint in aged mice. Mech Ageing Dev. 95:101–111. 1997. View Article : Google Scholar : PubMed/NCBI
12	Huebner JL, Otterness IG, Freund EM, Caterson B and Kraus VB: Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis. Arthritis Rheum. 41:877–890. 1998. View Article : Google Scholar : PubMed/NCBI
13	Mason RM, Chambers MG, Flannelly J, Gaffen JD, Dudhia J and Bayliss MT: The STR/ort mouse and its use as a model of osteoarthritis. Osteoarthritis Cartilage. 9:85–91. 2001. View Article : Google Scholar : PubMed/NCBI
14	Sokoloff L, Mickelsen O, Silverstein E, Jay GE Jr and Yamamoto RS: Experimental obesity and osteoarthritis. Am J Physiol. 198:765–770. 1960.PubMed/NCBI
15	Walton M: Obesity as an aetiological factor in the development of osteoarthrosis. Gerontology. 25:36–41. 1979. View Article : Google Scholar : PubMed/NCBI
16	Dreessen D and Halata Z: Age-related osteo-arthrotic degeneration of the temporomandibular joint in the mouse. Acta Anat (Basel). 139:91–96. 1990. View Article : Google Scholar : PubMed/NCBI
17	Arnett GW, Milam SB and Gottesman L: Progressive mandibular retrusion - idiopathic condylar resorption. Part I. Am J Orthod Dentofacial Orthop. 110:8–15. 1996. View Article : Google Scholar : PubMed/NCBI
18	Yamada K, Saito I, Hanada K and Hayashi T: Observation of three cases of temporomandibular joint osteoarthritis and mandibular morphology during adolescence using helical CT. J Oral Rehabil. 31:298–305. 2004. View Article : Google Scholar : PubMed/NCBI
19	Chen J, Sorensen KP, Gupta T, Kilts T, Young M and Wadhwa S: Altered functional loading causes differential effects in the subchondral bone and condylar cartilage in the temporomandibular joint from young mice. Osteoarthritis Cartilage. 17:354–361. 2009. View Article : Google Scholar : PubMed/NCBI