A single-nucleotide polymorphism in the interleukin‑1 receptor‑associated protein gene is associated with impaired glucose regulation and type 2 diabetes in a case‑controlled study

Wen,Qiang; Wu,Fangqin; Yang,Jinhua; Wu,Jingjing; Zhang,Xiaomin; He,Meian; Wu,Tangchun; Cheng,Longxian

doi:10.3892/br.2015.453

A single-nucleotide polymorphism in the interleukin‑1 receptor‑associated protein gene is associated with impaired glucose regulation and type 2 diabetes in a case‑controlled study

Authors:
- Qiang Wen
- Fangqin Wu
- Jinhua Yang
- Jingjing Wu
- Xiaomin Zhang
- Meian He
- Tangchun Wu
- Longxian Cheng
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Affiliations: Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
Published online on: April 20, 2015 https://doi.org/10.3892/br.2015.453
Pages: 549-553

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Abstract

Impaired glucose regulation (IGR), containing prediabetes and diabetes, is an inflammatory disease. The interleukin‑33 (IL‑33)/IL‑1 receptor‑like 1 and IL‑1/IL‑1 receptor (IL‑1R) pathways are involved and play opposite roles. While the IL‑1R‑associated protein (IL‑1Rap) is indispensible for the two pathways, the association between the single‑nucleotide polymorphisms (SNPs) of the IL‑1Rap gene and IGR has not been determined. TaqMan probe quantitative polymerase chain reaction was used to genotype 11 SNPs in the regions of the IL‑1Rap gene selected on the basis of linkage disequilibrium using the HapMap database in a study of 889 individuals (156 IGR patients in the case group and 733 non‑diabetic patients in the control group). Logistic regression was applied to control the potential confounders in the multivariate analysis. Among 11 SNPs, IL‑1Rap rs3773958 was associated with IGR. Further analysis showed that the odds ratios for GT and GT + GG carriers vs. TT carriers were 1.686 and 1.669, respectively, adjusted for gender, age, weight, waist, drinking, smoking, hypertension, alanine aminotransferase, total cholesterol and triglycerides. For rs3773958 in the non‑smoking subgroup, GT and GT + GG carriers had a significantly higher risk of IGR compared to the TT carriers. The same conclusions were drawn using data from non‑drinking and non‑overweight subgroups. However, interactions between rs3773958 and smoking, drinking or being overweight were not significant. In conclusion, rs3773958 in the IL‑1Rap gene region was associated with IGR.

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