Association between matrix metalloproteinase-2 and matrix metalloproteinase-9 polymorphisms and endometriosis: A systematic review and meta-analysis

  • Authors:
    • Lingli Xin
    • Qingxiang Hou
    • Qi Xiong
    • Xiaoping Ding
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  • Published online on: April 6, 2015     https://doi.org/10.3892/br.2015.447
  • Pages: 559-565
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Abstract

Matrix metalloproteinase-2 (MMP-2)-735C/T and MMP-9-1562C/T polymorphisms have been indicated in the predisposition to endometriosis. However, due to the small sample sizes of previous studies, the results remain inconclusive. The present meta‑analysis was conducted to detect the association between the two genetic polymorphisms and the risk of endometriosis by pooling all the available data. Electronic databases, including PubMed, Embase, Web of Science and CNKI, were searched comprehensively for studies examining a link between MMP‑2 and MMP‑9 polymorphisms and endometriosis. The strength of the association was assessed based on the pooled odds ratio with a 95% confidence interval, which was calculated using either the fixed‑ or random‑effect model. Following the inclusion criteria, 6 case‑control studies were included. The total number of participants was 2,486 (558 cases and 797 controls concerning the MMP‑9‑1562C/T polymorphism, and 525 cases and 606 controls concerning the MMP‑2‑735C/T polymorphism). No significant association was identified between the MMP‑2‑735C/T or MMP‑9‑1562C/T polymorphism and endometriosis. In further stratified analysis, no significant association was identified between the MMP‑9‑1562C/T polymorphism and endometriosis. The present meta‑analysis revealed no association between the MMP‑2‑735C/T and MMP‑9‑1562C/T polymorphisms and the risk of developing endometriosis. Considering the limitations of the meta‑analysis, well-designed studies with larger sample sizes are required.
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July-2015
Volume 3 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Xin L, Hou Q, Xiong Q and Ding X: Association between matrix metalloproteinase-2 and matrix metalloproteinase-9 polymorphisms and endometriosis: A systematic review and meta-analysis. Biomed Rep 3: 559-565, 2015
APA
Xin, L., Hou, Q., Xiong, Q., & Ding, X. (2015). Association between matrix metalloproteinase-2 and matrix metalloproteinase-9 polymorphisms and endometriosis: A systematic review and meta-analysis. Biomedical Reports, 3, 559-565. https://doi.org/10.3892/br.2015.447
MLA
Xin, L., Hou, Q., Xiong, Q., Ding, X."Association between matrix metalloproteinase-2 and matrix metalloproteinase-9 polymorphisms and endometriosis: A systematic review and meta-analysis". Biomedical Reports 3.4 (2015): 559-565.
Chicago
Xin, L., Hou, Q., Xiong, Q., Ding, X."Association between matrix metalloproteinase-2 and matrix metalloproteinase-9 polymorphisms and endometriosis: A systematic review and meta-analysis". Biomedical Reports 3, no. 4 (2015): 559-565. https://doi.org/10.3892/br.2015.447