Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease

Chang,Man‑Li; Cui,Can; Liu,Yan‑Hong; Pei,Li‑Chun; Shao,Bing

doi:10.3892/br.2015.455

Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease

Authors:
- Man‑Li Chang
- Can Cui
- Yan‑Hong Liu
- Li‑Chun Pei
- Bing Shao
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Affiliations: Department of Laboratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Geriatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Molecular Epidemiology, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China
Published online on: April 29, 2015 https://doi.org/10.3892/br.2015.455
Pages: 573-577

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Abstract

Due to the increase in the prevalence and incidence of allergic diseases, improving the sensitivity and specificity of screening indexes is critical. Total immunoglobulin E (IgE) is a traditional index for judging allergic diseases, while its specificity is relatively poor. Serum‑specific IgE (sIgE) is an objective index with high specificity in the diagnosis of allergic diseases. In the present research, the total IgE and sIgE of 3,721 patients with allergic diseases were analyzed to further illuminate the association between them. The data were derived from 3,721 patients. The serum‑sIgE to 14 types of common allergens and total IgE were detected. A total of 2,419 cases (65.0%) of 3,721 patients exhibited increasing total IgE and 1,215 patients (32.7%) exhibited positive sIgE. The consistency rate of the two indexes was 60.4%, and the κ‑value was 0.28. In 135 patients with normal total IgE, 82.2% exhibited one sIgE positive and 17.8% exhibited two or more sIgE positive. While the number of positive sIgE increased and the detecting level enhanced, the number of positive total IgE markedly increased. Patients (84.1%) with increasing total IgE were associated with positive sIgE, but the increase of total IgE could not be completely explained by the total accumulation of sIgE. Total IgE may play an important role on screening allergic disease while sIgE could be used as crucial evidence for allergy diagnosis. Although the consistency of the two methods was poor, neither total IgE nor sIgE could replace each other. Combining the two indexes with clinical manifestations together will improve the method.

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1	Asher MI, Stewart AW, Clayton T, Crane J, Ellwood PI, Mackay R, Mitchell E, Moyes C, Pattemore PK and Pearce N: Has the prevalence and severity of symptoms of asthma changed among children in New Zealand? ISAAC Phase Three. N Z Med J. 121:52–63. 2008.PubMed/NCBI
2	Liao MF, Liao MN, Lin SN, Chen JY and Huang JL: Prevalence of allergic diseases of schoolchildren in central taiwan. From ISAAC surveys 5 years apart. J Asthma. 46:541–545. 2009. View Article : Google Scholar : PubMed/NCBI
3	Lee SI: Prevalence of childhood asthma in Korea: International study of asthma and allergies in childhood. Allergy Asthma Immunol Res. 2:61–64. 2010. View Article : Google Scholar : PubMed/NCBI
4	Gold DR and Wright R: Population disparities in asthma. Annu Rev Public Health. 26:89–113. 2005. View Article : Google Scholar : PubMed/NCBI
5	Centers for Disease Control and Prevention (CDC): Forecasted state-specific estimates of self-reported asthma prevalence - United States, 1998. MMWR Morb Mortal Wkly Rep. 47:1022–1025. 1998.PubMed/NCBI
6	Centers for Disease Control and Prevention (CDC): Vital signs: Asthma prevalence, disease characteristics and self-management education: United States, 2001–2009. MMWR Morb Mortal Wkly Rep. 60:547–552. 2011.PubMed/NCBI
7	Pawankar R: Allergic rhinitis and asthma: The link, the new ARIA classification and global approaches to treatment. Curr Opin Allergy Clin Immunol. 4:1–4. 2004. View Article : Google Scholar : PubMed/NCBI
8	Meltzer EO, Blaiss MS, Derebery MJ, Mahr TA, Gordon BR, Sheth KK, Simmons AL, Wingertzahn MA and Boyle JM: Burden of allergic rhinitis: Results from the Pediatric Allergies in America survey. J Allergy Clin Immunol. 124:(Suppl 3). S43–S70. 2009. View Article : Google Scholar : PubMed/NCBI
9	Fineman SM: The burden of allergic rhinitis: Beyond dollars and cents. Ann Allergy Asthma Immunol. 88:(Suppl 1). 2–7. 2002. View Article : Google Scholar : PubMed/NCBI
10	Chang ML, Shao B, Liu YH, Li LL, Pei LC and Wang BY: Analysis of allergens in 5473 patients with allergic diseases in Harbin, China. Biomed Environ Sci. 26:886–893. 2013.PubMed/NCBI
11	Jiang RH, Zhu MJ, Jia YX, et al: Measurement and analysis of serum specific IgE and total IgE in children with chronic eczema. Chin J Lab Diagn. 13:935–937. 2009.(In Chinese).
12	Raulf M, Buters J, Chapman M, Cecchi L, de Blay F, Doekes G, et al: Monitoring of occupational and environmental aeroallergens - EAACI Position Paper. Concerted action of the EAACI IG Occupational Allergy and Aerobiology & Air Pollution. Allergy. 69:1280–1299. 2014. View Article : Google Scholar : PubMed/NCBI
13	Chandler HM, Coulter AR, Healey K, Kornitschuk M, MacGregor A and Hurrell JG: Monoclonal hybridoma antibodies against human IgE and their use in a rapid and sensitive enzyme immunoassay for the semiquantitative assessment of total IgE levels in human blood. Int Arch Allergy Appl Immunol. 72:267–272. 1983. View Article : Google Scholar : PubMed/NCBI
14	Eigenmann PA: Diagnosis of allergy syndromes: Do symptoms always mean allergy? Allergy. 60:(Suppl 79). 6–9. 2005. View Article : Google Scholar : PubMed/NCBI
15	Reid MJ, Kwasnicki JM, Moss RB and Cheung NK: Underestimation of specific immunoglobulin E by microtiter plate enzyme-linked immunosorbent assays. J Allergy Clin Immunol. 76:172–176. 1985. View Article : Google Scholar : PubMed/NCBI
16	Haas H, Becker WM, Maasch HJ and Schlaak M: Analysis of individual antibody reactivity of patients allergic to grass pollen using isoelectric focusing and immunoblotting. Immun Infekt. 13:24–25. 1985.(In German). PubMed/NCBI
17	Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, et al: Guidelines for the diagnosis and management of food allergy in the United States: Summary of the NIAID-sponsored expert panel report. Nutr Res. 31:61–75. 2011. View Article : Google Scholar : PubMed/NCBI
18	Herzum I, Blümer N, Kersten W and Renz H: Diagnostic and analytical performance of a screening panel for allergy. Clin Chem Lab Med. 43:963–966. 2005. View Article : Google Scholar : PubMed/NCBI
19	Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, et al: EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force: A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy. 56:813–824. 2001. View Article : Google Scholar : PubMed/NCBI