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Supplemental fermented plant product (‘Manda Koso’) reduces succinate and deoxycholate, as well as elevates IgA and mucin levels, in rats fed a high‑fat diet

  • Authors:
    • Yongshou Yang
    • Novita Vivi Sitanggang
    • Yukako Okazaki
    • Hiroyuki Tomotake
    • Kentaro Arita
    • Takayuki Ashida
    • Norihisa Kato

  • View Affiliations

  • Published online on: August 24, 2015     https://doi.org/10.3892/br.2015.506
  • Pages: 787-791

  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

‘Manda Koso’ is a commercial fermented plant product (FPP) made from 53 types of fruits and vegetables that have been fermented for >3 years and 3 months. We hypothesized that FPP intake improves the luminal environment of rats fed a high‑fat diet. Thus, the present study examined the effects of consumption of 5% FPP diet for 3 weeks on colonic luminal parameters in rats fed a 30% beef tallow diet. Food intake and body weight gain were unaffected. Consumption of the FPP diet did not influence the proportions of Bifidobacterium, Lactobacillus, Bacteroides, Prevotella or Clostridium in cecal contents. However, the FPP diet caused a significant reduction (‑88%) in the level of cecal succinate, a putative inflammatory signal (P<0.01), but did not affect the levels of n‑butyrate, propionate, acetate and lactate. The fecal levels of deoxycholate and hyodeoxycholate, which are toxic bile acids, were also significantly reduced by the FPP diet (P<0.05). The FPP diet significantly increased fecal immunoglobulin A and mucins responsible for intestinal immune and barrier functions (P<0.05). The results suggest that the consumption of FPP is beneficial for the colonic luminal environment in rats fed a high‑fat diet.
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November-2015
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Spandidos Publications style
Yang Y, Sitanggang NV, Okazaki Y, Tomotake H, Arita K, Ashida T and Kato N: Supplemental fermented plant product (‘Manda Koso’) reduces succinate and deoxycholate, as well as elevates IgA and mucin levels, in rats fed a high‑fat diet. Biomed Rep 3: 787-791, 2015
APA
Yang, Y., Sitanggang, N.V., Okazaki, Y., Tomotake, H., Arita, K., Ashida, T., & Kato, N. (2015). Supplemental fermented plant product (‘Manda Koso’) reduces succinate and deoxycholate, as well as elevates IgA and mucin levels, in rats fed a high‑fat diet. Biomedical Reports, 3, 787-791. https://doi.org/10.3892/br.2015.506
MLA
Yang, Y., Sitanggang, N. V., Okazaki, Y., Tomotake, H., Arita, K., Ashida, T., Kato, N."Supplemental fermented plant product (‘Manda Koso’) reduces succinate and deoxycholate, as well as elevates IgA and mucin levels, in rats fed a high‑fat diet". Biomedical Reports 3.6 (2015): 787-791.
Chicago
Yang, Y., Sitanggang, N. V., Okazaki, Y., Tomotake, H., Arita, K., Ashida, T., Kato, N."Supplemental fermented plant product (‘Manda Koso’) reduces succinate and deoxycholate, as well as elevates IgA and mucin levels, in rats fed a high‑fat diet". Biomedical Reports 3, no. 6 (2015): 787-791. https://doi.org/10.3892/br.2015.506