Molecular characterization of human Torque Teno virus

Wei,Youping; Chen,Minyang; Yang,Xia; Zhang,Liming; Rao,Lihua; Yuan,Feifang; Wang,Yangqin; Gong,Jing; Li,Lianping

doi:10.3892/br.2015.508

Molecular characterization of human Torque Teno virus

Authors:
- Youping Wei
- Minyang Chen
- Xia Yang
- Liming Zhang
- Lihua Rao
- Feifang Yuan
- Yangqin Wang
- Jing Gong
- Lianping Li
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Affiliations: Nanchang Hospital of Integrated Traditional Chinese and Western Medicine, Nanchang, Jiangxi 330003, P.R. China
Published online on: August 26, 2015 https://doi.org/10.3892/br.2015.508
Pages: 821-826

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Abstract

The present study analyzed the presence of human Torque Teno virus (TTV) in hospitalized patients from different departments. In total, 378 serum specimens were collected from the patients (171 with cardiovascular disease, 192 with tumor and 15 with gastroenteritis) and analyzed by ELISA and nest‑polymerase chain reaction (PCR) to detect the presence of TTV. The results showed that 64 specimens (17%) were TTV positive from detection with the human ELISA kit, and the patients aged <30 years have a higher prevalence. TTV in males was more common than in female patients. In addition, nest‑PCR was used to detect TTV within different phylogenetic groups among the 64 specimens, and the results showed that groups 1 (TA278 strain), 4 (KC009) and 5 (CT39) were much more prevalent than groups 2 (PMV isolate) and 3 (11 genotypes) in the different departmental patients.

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