Candidate single‑nucleotide polymorphisms and cerebral palsy: A case‑control study

He,Xiao‑Guang; Peng,Qi; Chen,Yan‑Hua; He,Ting; Huang,Hui; Ma,Ze‑Ke; Fan,Xue‑Jin; Luo,Ling; Liu,Shao‑Ji; Lu,Xiao‑Mei

doi:10.3892/br.2015.519

Candidate single‑nucleotide polymorphisms and cerebral palsy: A case‑control study

Authors:
- Xiao‑Guang He
- Qi Peng
- Yan‑Hua Chen
- Ting He
- Hui Huang
- Ze‑Ke Ma
- Xue‑Jin Fan
- Ling Luo
- Shao‑Ji Liu
- Xiao‑Mei Lu
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Affiliations: Department of Pediatrics, Dongguan Children's Hospital, Dongguan, Guangdong 523325, P.R. China, BGI‑Shenzhen, Shenzhen, Guangdong 518083, P.R. China
Published online on: September 25, 2015 https://doi.org/10.3892/br.2015.519
Pages: 849-852

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Abstract

Certain genetic polymorphisms have been suggested to be associated with cerebral palsy; the candidate genes are involved in thrombophilia, inflammation and preterm labor, but the mechanism remains to be elucidated. The aim of the present study was to investigate the associations between selected single‑nucleotide polymorphisms (SNPs) and cerebral palsy among children. A case‑control study was conducted, including 74 infants with cerebral palsy (case group) and 99 healthy infants (control group). The distributions of the allele and genotype frequencies were examined for the total cerebral palsy patient population in addition to subgroups divided according to gestational age (preterm versus full‑term). The results showed that the rs1042714 variant in adrenergic receptor β‑2 (ADRB2) and heterozygosity for ADRB2 were associated with the cerebral palsy risk among the preterm infants. No significant differences in the allele or genotype frequencies were observed between the total cerebral palsy patient population and controls for the eight SNPs investigated.

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1	Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bax M, Damiano D, Dan B and Jacobsson B: A report: The definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl. 109:8–14. 2007.PubMed/NCBI
2	McHale DP, Jackson AP, Campbell W, Levene MI, Corry P, Woods CG, Lench NJ, Mueller RF and Markham AF: A gene for ataxic cerebral palsy maps to chromosome 9p12-q12. Eur J Hum Genet. 8:267–272. 2000. View Article : Google Scholar : PubMed/NCBI
3	Menkes JH and Flores-Sarnat L: Cerebral palsy due to chromosomal anomalies and continuous gene syndromes. Clin Perinatol. 33:481–501. 2006. View Article : Google Scholar : PubMed/NCBI
4	Mutch L, Alberman E, Hagberg B, Kodama K and Perat MV: Cerebral palsy epidemiology: Where are we now and where are we going? Dev Med Child Neurol. 34:547–551. 1992. View Article : Google Scholar : PubMed/NCBI
5	Blair E and Watson L: Epidemiology of cerebral palsy. Semin Fetal Neonatal Med. 11:117–125. 2006. View Article : Google Scholar : PubMed/NCBI
6	Paneth N, Hong T and Korzeniewski S: The descriptive epidemiology of cerebral palsy. Clin Perinatol. 33:251–267. 2006. View Article : Google Scholar : PubMed/NCBI
7	Liu JM, Li S, Lin Q and Li Z: Prevalence of cerebral palsy in China. Int J Epidemiol. 28:949–954. 1999. View Article : Google Scholar : PubMed/NCBI
8	Rajab A, Yoo SY, Abdulgalil A, Kathiri S, Ahmed R, Mochida GH, Bodell A, Barkovich AJ and Walsh CA: An autosomal recessive form of spastic cerebral palsy (CP) with microcephaly and mental retardation. Am J Med Genet A. 140:1504–1510. 2006. View Article : Google Scholar : PubMed/NCBI
9	Wu D, Zou YF, Xu XY, Feng XL, Yang L, Zhang GC, Bu XS and Tang JL: The association of genetic polymorphisms with cerebral palsy: A meta-analysis. Dev Med Child Neurol. 53:217–225. 2011. View Article : Google Scholar : PubMed/NCBI
10	Stanley F, Blair E and Alberman E: Cerebral Palsies: Epidemiology and Causal Pathways. 151:London: MacKeith Press. 2000.
11	Bundey S and Griffiths MI: Recurrence risks in families of children with symmetrical spasticity. Dev Med Child Neurol. 19:179–191. 1977. View Article : Google Scholar : PubMed/NCBI
12	Hemminki K, Sundquist K and Li X: Familial risks for main neurological diseases in siblings based on hospitalizations in Sweden. Twin Res Hum Genet. 9:580–586. 2006. View Article : Google Scholar : PubMed/NCBI
13	Raju TN, Nelson KB, Ferriero D and Lynch JK: NICHD-NINDS Perinatal Stroke Workshop Participants: Ischemic perinatal stroke: Summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics. 120:609–616. 2007. View Article : Google Scholar : PubMed/NCBI
14	Gibson CS, MacLennan AH, Goldwater PN, Haan EA, Priest K and Dekker GA: South Australian Cerebral Palsy Research Group: The association between inherited cytokine polymorphisms and cerebral palsy. Am J Obstet Gynecol. 194:674.e1–674.e11. 2006. View Article : Google Scholar
15	Nelson KB, Dambrosia JM, Iovannisci DM, Cheng S, Grether JK and Lammer E: Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatr Res. 57:494–499. 2005. View Article : Google Scholar : PubMed/NCBI
16	Gibson CS, Maclennan AH, Dekker GA, Goldwater PN, Sullivan TR, Munroe DJ, Tsang S, Stewart C and Nelson KB: Candidate genes and cerebral palsy: A population-based study. Pediatrics. 122:1079–1085. 2008. View Article : Google Scholar : PubMed/NCBI
17	Resch BE, Ducza E, Gáspár R and Falkay G: Role of adrenergic receptor subtypes in the control of human placental blood vessels. Mol Reprod Dev. 66:166–171. 2003. View Article : Google Scholar : PubMed/NCBI
18	Loza MJ, Peters SP, Foster S, Khan IU and Penn RB: beta-Agonist enhances type 2 T-cell survival and accumulation. J Allergy Clin Immunol. 119:235–244. 2007. View Article : Google Scholar : PubMed/NCBI
19	Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, et al: C-reactive protein, an ‘intermediate phenotype’ for inflammation: Human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 25:329–343. 2007. View Article : Google Scholar : PubMed/NCBI
20	McGuire W, Hill AV, Allsopp CE, Greenwood BM and Kwiatkowski D: Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature. 371:508–510. 1994. View Article : Google Scholar : PubMed/NCBI
21	Zak I, Sarecka-Hujar B, Kopyta I, Emich-Widera E, Marszal E, Wendorff J and Jachowicz-Jeszka J: The T allele of the 677C>T polymorphism of methylenetetrahydrofolate reductase gene is associated with an increased risk of ischemic stroke in Polish children. J Child Neurol. 24:1262–1267. 2009. View Article : Google Scholar : PubMed/NCBI
22	Pogliani L, Muggiasca L, Arrigoni L, Rossi E and Zuccotti G: Maternal methylenetetrahydrofolate reductase (MTHFR) homozygosity and neonatal outcome: Follow-up of 42 pregnancies at risk. J Child Neurol. 25:701–704. 2010. View Article : Google Scholar : PubMed/NCBI
23	Pileri P, Franchi F, Cetin I, Mandò C, Antonazzo P, Ibrahim B, Rossi F and Biguzzi E: Maternal and fetal thrombophilia in intrauterine growth restriction in the presence or absence of maternal hypertensive disease. Reprod Sci. 17:844–848. 2010. View Article : Google Scholar : PubMed/NCBI
24	Rath W: Pre-eclampsia and inherited thrombophilia: A reappraisal. Semin Thromb Hemost. 37:118–124. 2011. View Article : Google Scholar : PubMed/NCBI