Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension

Yan,Guozhen; He,Junfeng; Yu,Yueli; Liu,Yang; Yuan,Yanfen; Guo,Zhiyong

doi:10.3892/br.2015.526

Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension

Authors:
- Guozhen Yan
- Junfeng He
- Yueli Yu
- Yang Liu
- Yanfen Yuan
- Zhiyong Guo
View Affiliations

Affiliations: Department of Ultrasound, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China
Published online on: October 6, 2015 https://doi.org/10.3892/br.2015.526
Pages: 51-54

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The continuous changes in pulmonary hemodynamic properties in hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH) have not been fully characterized in large animal models of HPS and PoPH. Beagle dog models of HPS and PoPH were induced by chronic common bile duct ligation and Sephadex microspheres, respectively. The model was validated by catheter examination and pathological analyses, and the hemodynamic characteristics of the models were observed. The results revealed that the cross‑sectional area of the blood vessel was significantly increased in HPS models, but it was significantly decreased in the PoPH models. Furthermore, the resistance of pulmonary circulation was elevated in models of HPS, but it was decreased in models of PoPH. The present findings renew the traditional view that pulmonary hypertension is due to the enhanced peripheral resistance.

View Figures

View References

1	Aldenkortt F, Aldenkortt M, Caviezel L, Waeber JL, Weber A and Schiffer E: Portopulmonary hypertension and hepatopulmonary syndrome. World J Gastroenterol. 20:8072–8081. 2014. View Article : Google Scholar : PubMed/NCBI
2	Dienstag JL and Cosimi AB: Liver transplantation - a vision realized. N Engl J Med. 367:1483–1485. 2012. View Article : Google Scholar : PubMed/NCBI
3	Mantz FA Jr and Craige E: Portal axis thrombosis with spontaneous portacaval shunt and resultant cor pulmonale. AMA Arch Pathol. 52:91–97. 1951.PubMed/NCBI
4	Hoffbauer FW and Rydell R: Multiple pulmonary arteriovenous fistulas in juvenile cirrhosis. Am J Med. 21:450–460. 1956. View Article : Google Scholar : PubMed/NCBI
5	Fauconnet P, Klopfenstein CE and Schiffer E: Hepatopulmonary syndrome: The anaesthetic considerations. Eur J Anaesthesiol. 30:721–730. 2013. View Article : Google Scholar : PubMed/NCBI
6	Krowka MJ: Management of pulmonary complications in pretransplant patients. Clin Liver Dis. 15:765–777. 2011. View Article : Google Scholar : PubMed/NCBI
7	Fritz JS, Fallon MB and Kawut SM: Pulmonary vascular complications of liver disease. Am J Respir Crit Care Med. 187:133–143. 2013. View Article : Google Scholar : PubMed/NCBI
8	Machicao VI, Balakrishnan M and Fallon MB: Pulmonary complications in chronic liver disease. Hepatology. 59:1627–1637. 2014. View Article : Google Scholar : PubMed/NCBI
9	Møller S, Henriksen JH and Bendtsen F: Extrahepatic complications to cirrhosis and portal hypertension: Haemodynamic and homeostatic aspects. World J Gastroenterol. 20:15499–15517. 2014. View Article : Google Scholar : PubMed/NCBI
10	Jin W, Deng L, Zhang Q, Lin D, Zhu J, Chen Y, Chen B and Li J: A canine portal hypertension model induced by intra-portal administration of Sephadex microsphere. J Gastroenterol Hepatol. 25:778–785. 2010. View Article : Google Scholar : PubMed/NCBI
11	Yang Y, Chen B, Chen Y, Zu B, Yi B and Lu K: A comparison of two common bile duct ligation methods to establish hepatopulmonary syndrome animal models. Lab Anim. 49:71–79. 2015. View Article : Google Scholar : PubMed/NCBI
12	Easter DW, Wade JB and Boyer JL: Structural integrity of hepatocyte tight junctions. J Cell Biol. 96:745–749. 1983. View Article : Google Scholar : PubMed/NCBI
13	Fallon MB, Abrams GA, Luo B, Hou Z, Dai J and Ku DD: The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome. Gastroenterology. 113:606–614. 1997. View Article : Google Scholar : PubMed/NCBI
14	Yang W, Hu B, Wu W, Batra S, Blackburn MR, Alcorn JL, Fallon MB and Zhang J: Alveolar type II epithelial cell dysfunction in rat experimental hepatopulmonary syndrome (HPS). PLoS One. 9:e1134512014. View Article : Google Scholar : PubMed/NCBI
15	Groszmann RJ, Glickman M, Blei AT, Storer E and Conn HO: Wedged and free hepatic venous pressure measured with a balloon catheter. Gastroenterology. 76:253–258. 1979.PubMed/NCBI
16	Kasai H, Sugiura T, Tanabe N, Sakurai Y, Yahaba M, Matsuura Y, Shigeta A, Kawata N, Sakao S, Kasahara Y, et al: Electrocardiogram-gated 320-slice multidetector computed tomography for the measurement of pulmonary arterial distensibility in chronic thromboembolic pulmonary hypertension. PLoS One. 9:e1115632014. View Article : Google Scholar : PubMed/NCBI
17	Fallon MB, Abrams GA, McGrath JW, Hou Z and Luo B: Common bile duct ligation in the rat: A model of intrapulmonary vasodilatation and hepatopulmonary syndrome. Am J Physiol. 272:G779–G784. 1997.PubMed/NCBI
18	Zhang J, Luo B, Tang L, Wang Y, Stockard CR, Kadish I, Van Groen T, Grizzle WE, Ponnazhagan S and Fallon MB: Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Gastroenterology. 136:1070–1080. 2009. View Article : Google Scholar : PubMed/NCBI
19	Chan SY and Loscalzo J: Pathogenic mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol. 44:14–30. 2008. View Article : Google Scholar : PubMed/NCBI
20	Stenmark KR and McMurtry IF: Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: A time for reappraisal? Circ Res. 97:95–98. 2005. View Article : Google Scholar : PubMed/NCBI
21	Zaiman A, Fijalkowska I, Hassoun PM and Tuder RM: One hundred years of research in the pathogenesis of pulmonary hypertension. Am J Respir Cell Mol Biol. 33:425–431. 2005. View Article : Google Scholar : PubMed/NCBI
22	Tabima DM and Chesler NC: The effects of vasoactivity and hypoxic pulmonary hypertension on extralobar pulmonary artery biomechanics. J Biomech. 43:1864–1869. 2010. View Article : Google Scholar : PubMed/NCBI
23	Dyer K, Lanning C, Das B, Lee PF, Ivy DD, Valdes-Cruz L and Shandas R: Noninvasive Doppler tissue measurement of pulmonary artery compliance in children with pulmonary hypertension. J Am Soc Echocardiogr. 19:403–412. 2006. View Article : Google Scholar : PubMed/NCBI
24	Rossmann JS: Elastomechanical properties of bovine veins. J Mech Behav Biomed Mater. 3:210–215. 2010. View Article : Google Scholar : PubMed/NCBI
25	Singh C and Sager JS: Pulmonary complications of cirrhosis. Medical Clin North Am. 93871–883. (viii)2009. View Article : Google Scholar
26	Rodríquez-Roisin R, Krowka MJ, Hervé P and Fallon MB: ERS (European Respiratory Society) Task Force-PHD Scientific Committee: Highlights of the ERS Task Force on pulmonary-hepatic vascular disorders (PHD). J Hepatol. 42:924–927. 2005. View Article : Google Scholar : PubMed/NCBI
27	Chung S, Lee K, Chang SA and Kim DK: Aggravation of hepatopulmonary syndrome after sildenafil treatment in a patient with coexisting portopulmonary hypertension. Korean Circ J. 45:77–80. 2015. View Article : Google Scholar : PubMed/NCBI