Kuromoji (Lindera umbellata) essential oil-induced apoptosis and differentiation in human leukemia HL-60 cells

Maeda,Hayato; Yamazaki,Mao; Katagata,Yohtaro

doi:10.3892/etm.2011.357

Kuromoji (Lindera umbellata) essential oil-induced apoptosis and differentiation in human leukemia HL-60 cells

Authors:
- Hayato Maeda
- Mao Yamazaki
- Yohtaro Katagata
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Affiliations: Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Aomori 036-8561, Japan
Published online on: September 27, 2011 https://doi.org/10.3892/etm.2011.357
Pages: 49-52

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Abstract

Essential oils diluted from certain plants have been shown to have antitumor activity against several human tumor cell lines. Kuromoji (Lindera umbellata) essential oil (KEO) has long been used in Japan as a traditional medicine. KEO and its major chemical constituent, linalool, were investigated in this study for their ability to induce apoptosis and differentiation in human leukemia HL-60 cells. HL-60 cells were treated with 5 or 50 µg/ml KEO or linalool for 24 or 48 h. Then, cell proliferation and apoptosis induction were estimated. In addition, HL-60 cells are known to differentiate into granulocyte or monocytes by a variety of compounds. Therefore, the effect of KEO or linalool on differentiation of HL-60 cells was assessed by Giemsa stain and a nitroblue tetrazolium reduction assay. Cells treated with KEO or linalool for 48 h showed significantly suppressed cell proliferation, with induced apoptosis. Moreover, KEO and linalool promoted cell differentiation. Treatment with KEO cells at the same dose as linalool showed an almost identical effect on HL-60 cells. These results suggest that KEO and linalool have efficacy as anticancer therapeutic products.

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1.	G KleinCancer, apoptosis, and nonimmune surveillanceCell Death Differ11317200410.1038/sj.cdd.440134214615800
2.	KH LeeAnticancer drug design based on plant-derived natural productsJ Biomed Sci4236250199910420081
3.	GB PierceWC SpeersTumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiationCancer Res481996200419882450643
4.	HM BeereJA HickmanDifferentiation: a suitable strategy for cancer chemotherapy?Anticancer Drug Des429932219938240658
5.	AE EdrisPharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a reviewPhytother Res4308323200710.1002/ptr.207217199238
6.	A KumarF MalikS BhushanVK SethiAK ShahiJ KaurSC TanejaGN QaziJ SinghAn essential oil and its major constituent isointermedeol induce apoptosis by increased expression of mitochondrial cytochrome c and apical death receptors in human leukaemia HL-60 cellsChem Biol Interact3332347200810.1016/j.cbi.2007.10.003
7.	LC ChiangW ChiangMY ChangLT NgCC LinAntileukemic activity of selected natural products in TaiwanAm J Chin Med313746200310.1142/S0192415X0300082512723753
8.	R RavizzaMB GariboldiR MolteniE MontiLinalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cellsOncol Rep20625630200818695915
9.	MR LoizzoR TundisF MenichiniAM SaabGA StattiF MenichiniAntiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cellsCell Prolif4110021012200810.1111/j.1365-2184.2008.00561.x19040575
10.	SY PaikKH KohSM BeakSH PaekJA KimThe essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen speciesBiol Pharm Bull28802807200515863882
11.	Y GuZ TingX QiuX ZhangX GanY FangX XuR XuLinalool preferentially induces robust apoptosis of various leukemia cells via upregulating p53 and cyclin-dependent kinase inhibitorsToxicology2681924201010.1016/j.tox.2009.11.01319922762
12.	T GotoN TakahashiS HiraiT KawadaVarious terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolismPPAR Res2010483958201010.1155/2010/48395820613991
13.	S CastaigneC ChomienneMT DanielP BalleriniR BergerP FenauxL DegosAll-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical resultsBlood7691704170919902224119
14.	S MishimaY InohY NaritaS OhtaT SakamotoY ArakiKM SuzukiY AkaoY NozawaIdentification of caffeoylquinic acid derivatives from Brazilian propolis as constituents involved in induction of granulocytic differentiation of HL-60 cellsBioorg Med Chem1358145818200510.1016/j.bmc.2005.05.04415993085
15.	HC KuoWH KuoYJ LeeCJ WangTH TsengEnhancement of acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cellsToxicol Appl Pharmacol2168088200610.1016/j.taap.2006.04.00716766008
16.	TR BreitmanSE SelonickSJ CollinsInduction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acidProc Natl Acad Sci USA7729362940198010.1073/pnas.77.5.2936
17.	H MotekiH HibasamiY YamadaH KatsuzakiK ImaiT KomiyaSpecific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not in a human stomach cancer cell lineOncol Rep9757760200212066204
18.	JA SokoloskiWF HodnickST MayneC CinquinaCS KimAC SartorelliInduction of the differentiation of HL-60 promyelocytic leukemia cells by vitamin E and other antioxidants in combination with low levels of vitamin D3: possible relationship to NF-kappaBLeukemia1115461553199710.1038/sj.leu.24007869305611
19.	E LinneyRetinoic acid receptors transcription factors modulating gene regulation, development, and differentiationCurr Top Dev Biol27309350199210.1016/S0070-2153(08)60538-41330444
20.	KA RobertsonB EmamiL MuellerSJ CollinsMultiple members of the retinoic acid receptor family are capable of mediating the granulocytic differentiation of HL-60 cellsMol Cell Biol123743374919921324405
21.	P FenauxS CastaigneC ChomienneH DombretL DegosAll trans retinoic acid treatment for patients with acute promyelocytic leukemiaLeukemia6646619921548938
22.	M CornicC ChomienneInduction of retinoid resistance by all-trans retinoic acid in acute promyelocytic leukemia after remissionLeuk Lymphoma18249257199510.3109/104281995090596158535190
23.	J JagdeoR CampbellT LongJ MugliaG TelangL Robinson-BostomSweet’s syndrome-like neutrophilic lobular panniculitis associated with all-trans-retinoic acid chemotherapy in a patient with acute promyelocytic leukemiaJ Am Acad Dermatol566906932007