Tumor necrosis factor-α -308G/A polymorphism is associated with active vitiligo vulgaris in a northeastern Mexican population

Salinas-Santander,Mauricio; Díaz-García,Daniel; Rojas-Martínez,Augusto; Cantú-Salinas,Cristina; Sánchez-Domínguez,Celia; Reyes-López,Miguel; Cerda-Flores,Ricardo  M.; Ocampo-Candiani,Jorge; Ortiz-López,Rocío

doi:10.3892/etm.2012.508

Tumor necrosis factor-α -308G/A polymorphism is associated with active vitiligo vulgaris in a northeastern Mexican population

Authors:
- Mauricio Salinas-Santander
- Daniel Díaz-García
- Augusto Rojas-Martínez
- Cristina Cantú-Salinas
- Celia Sánchez-Domínguez
- Miguel Reyes-López
- Ricardo M. Cerda-Flores
- Jorge Ocampo-Candiani
- Rocío Ortiz-López
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Affiliations: Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, Molecular Biology, Genomics and Sequencing Unit, Center for Research and Development in the Health Sciences, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, Dermatology Service, Hospital Universitario ‘Dr. José Eleuterio González’, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, Conservation Medicine, Genomics and Biotechnology Center-IPN, Cd. Reynosa, Tamaulipas, Mexico, Nursery School Faculty, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico
Published online on: March 9, 2012 https://doi.org/10.3892/etm.2012.508
Pages: 893-897

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Abstract

Vitiligo is a skin disease characterized by depigmentation. Its etiopathogenesis is unclear, but it has been associated with autoimmune processes. Gene polymorphisms in the tumor necrosis factor-α (TNF-α) have been associated with several imflammatory diseases. In particular, the -308G/A polymorphism in the gene promoter region has been reported to be associated with increased plasma levels of TNF-α and with an increased risk to develop autoimmune diseases. To date, this polymorphism has not been associated with vitiligo. To assess a possible association between the TNF-α -308G/A and vitiligo vulgaris (VV), 198 vitiligo patients and 395 control subjects were recruited for the study. A complete demographic and clinical profile of each case was registered to analyze the possible risk factors of vitiligo. Genomic DNA isolated from peripheral blood was subjected to PCR-RFLP for genotyping of the TNF-α -308G/A polymorphism. Causal associations were determined by χ2 test and their respective OR was assessed in a 2x2 contingency table. When population variables of type of vitiligo, gender, age of disease onset, and active disease status were considered, an association between active VV and the TNF-α GA genotype was found (P=0.0295, OR=2.0; 95% CI 1.01‑3.93). All other variables were irrelevant to vitiligo. Our data suggest a possible association between the TNF-α -308 GA genotype and the active form of VV in a Mexican population.

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