Association of angiotensin converting enzyme gene polymorphism with tachycardia cardiomyopathy

  • Authors: Pramod M. Deshmukh, Rajan Krishnamani, Mary Romanyshyn, Andrew K. Johnson, John D. Noti
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  • Published online on: Monday, March 1, 2004
  • Pages: 455-458
  • DOI: 10.3892/ijmm.13.3.455

Abstract

Despite incessant tachycardia, not all patients develop tachycardia-mediated cardiomyopathy. The cardiac renin-angiotensin system may be involved in cardiac remodelling and fibrosis. The level of angiotension-converting enzyme (ACE) in the serum is associated with a 287 bp insertion (I)/deletion (D) polymorphism in intron 16 of the ACE gene. The DD genotype is associated with increased serum ACE levels and a higher incidence of idiopathic dilated and ischemic cardiomyopathy. The objective of this study was to assess whether the ACE gene I/D polymorphism is responsible for development of tachycardia-mediated cardiomyopathy. We identified 20 consecutive patients with persistent tachycardia and cardiomyopathy who showed significant improvement in ejection fraction after rate control (group A, tachycardia cardiomyopathy group). We compared the I/D genotype frequency of group A with the gene frequency of a separate group of 20 patents who, despite rapid atrial arrhythmias had preserved left ventricular ejection fraction (group B, tachycardia without cardiomyopathy group). These two groups were then compared with 24 healthy normal volunteers (group C). After a mean follow-up of 30 months, group A patients showed improvement in ejection fraction from 20±7 to 43±9% (p<0.001). Group A had a significantly higher frequency of the DD genotype than groups B and C (p-value <0.035 and <0.009 respectively). The profile of group B patients was intermediate between normal and patients with tachycardia-mediated cardiomyopathy. I/D polymorphism of the ACE gene may account for cardiomyopathy secondary to tachycardia.
Journal Cover

March 2004
Volume 13 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Deshmukh, P., Krishnamani, R., Romanyshyn, M., Johnson, A., & Noti, J. (2004). Association of angiotensin converting enzyme gene polymorphism with tachycardia cardiomyopathy. International Journal of Molecular Medicine, 13(3), 455-458.
MLA
Deshmukh, Krishnamani, Romanyshyn, Johnson, and John Noti. "Association of angiotensin converting enzyme gene polymorphism with tachycardia cardiomyopathy." International Journal of Molecular Medicine International Journal of Molecular Medicine 13.3 (2004): 455-458.
Chicago
Deshmukh, Krishnamani, Romanyshyn, Johnson, and John Noti. "Association of angiotensin converting enzyme gene polymorphism with tachycardia cardiomyopathy." International Journal of Molecular Medicine International Journal of Molecular Medicine 13 no. 3 (2004): 455-458.