Effects of arginine vasopressin (AVP) on the pituitary-thyroid axis in the rat: Evidence that endogenous AVP, acting via V1 receptors, lowers TSH blood concentration

  • Authors:
    • Ludwik K. Malendowicz
    • Raffaella Spinazzi
    • Krzysztof W. Nowak
    • Gastone G. Nussdorfer
    • Mariola Majchrzak
  • Corresponding author:
  • View Affiliations

  • Published online on: Tuesday, June 1, 2004
  • Pages: 869-872 DOI: 10.3892/ijmm.13.6.869

Abstract

We have investigated the effects of the prolonged administration (2 or 8 days) of arginine-vasopressin (AVP), alone or with antagonists of its V1 and V2 receptors (V1-Ra and V2-Ra), on the rat pituitary-thyroid axis. In the 8-day, but not 2-day experiments, AVP raised thyroid weight, and the effect was prevented by V1-Ra. Morphometry showed that the AVP-induced increase in thyroid weight was mainly due to a rise in the stroma volume. In the 2-day, but not 8-day experiments, AVP lowered TSH plasma concentration, and the effect was annulled by V1-Ra. V1-Ra was ineffective per se, while V2-Ra lowered TSH blood level. AVP administration increased the level of circulating thyroid hormones, especially thyroxine (free and total T4). In the 2-day, but not 8-day experiments, this effect of AVP was blocked by both V1-Ra and V2-Ra. When administered alone V1-Ra and V2-Ra induced a small, but significant rise in T4 plasma concentration in both the 2-day and 8-day experiments. Collectively, these findings indicate that: i) AVP administration exerts a transient inhibitory effect on TSH secretion, and a more prolonged stimulatory action on thyroid secretion and growth, both of which are mainly mediated by the V1-R subtype; and ii) endogenous AVP exerts a clearcut tonic inhibitory effect on pituitary TSH release and doubtful regulatory actions on the thyroid gland.
Journal Cover

June 2004
Volume 13 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
2014 I.F. (Expected) ≥ 2.327 Ranked #27/122 Medicine Research and Experimental
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APA
Malendowicz, L.K., Spinazzi, R., Nowak, K.W., Nussdorfer, G.G., & Majchrzak, M. (2004). Effects of arginine vasopressin (AVP) on the pituitary-thyroid axis in the rat: Evidence that endogenous AVP, acting via V1 receptors, lowers TSH blood concentration. International Journal of Molecular Medicine, 13, 869-872. http://dx.doi.org/10.3892/ijmm.13.6.869
MLA
Malendowicz, L. K., Spinazzi, R., Nowak, K. W., Nussdorfer, G. G., Majchrzak, M."Effects of arginine vasopressin (AVP) on the pituitary-thyroid axis in the rat: Evidence that endogenous AVP, acting via V1 receptors, lowers TSH blood concentration". International Journal of Molecular Medicine 13.6 (2004): 869-872.
Chicago
Malendowicz, L. K., Spinazzi, R., Nowak, K. W., Nussdorfer, G. G., Majchrzak, M."Effects of arginine vasopressin (AVP) on the pituitary-thyroid axis in the rat: Evidence that endogenous AVP, acting via V1 receptors, lowers TSH blood concentration". International Journal of Molecular Medicine 13, no. 6 (2004): 869-872. http://dx.doi.org/10.3892/ijmm.13.6.869