ZNF268, a novel krüppel-like zinc finger protein, is implicated in early human liver development

  • Authors:
    • Yan Sun
    • Huanjie Shao
    • Zhi Li
    • Jun Liu
    • Li Gao
    • Xiao Peng
    • Yunlian Meng
    • Wenxin Li
  • View Affiliations

  • Published online on: December 1, 2004     https://doi.org/10.3892/ijmm.14.6.971
  • Pages: 971-975
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The advancement in gene knockout and transgenesis have brought about enormous improvement in our understanding of mouse embryogenesis in the past decade or so. On the other hand, relatively little is known about human embryogenesis due largely to the lack of easy access to human embryos and tissues for biomedical studies. We have previously isolated a novel zinc finger gene, ZNF268, from a 3-week-old human embryo cDNA library in an effort to identify genes important for human embryonic development. To investigate the potential involvement of ZNF268 in human embryogenesis, we report here the spatial and temporal regulation of its expression during development. Northern blot and Western blot analyses revealed that ZNF268 is expressed in early embryos, predominantly, if not exclusively, in fetal liver with little detectable expression in other fetal organs. Interestingly, unlike most zinc finger proteins, ZNF268 protein was found to be localized mainly in the cytoplasm of embryonic hepatocytes. This subcellular localization was substantiated by the localization of EGFP-ZNF268 fusion protein overexpressed in the transfected COS7 cells. These results suggest that ZNF268 plays a role in early human liver development most likely by functioning through a cytoplasmic mechanism.

Related Articles

Journal Cover

December 2004
Volume 14 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Shao H, Li Z, Liu J, Gao L, Peng X, Meng Y and Li W: ZNF268, a novel krüppel-like zinc finger protein, is implicated in early human liver development. Int J Mol Med 14: 971-975, 2004
APA
Sun, Y., Shao, H., Li, Z., Liu, J., Gao, L., Peng, X. ... Li, W. (2004). ZNF268, a novel krüppel-like zinc finger protein, is implicated in early human liver development. International Journal of Molecular Medicine, 14, 971-975. https://doi.org/10.3892/ijmm.14.6.971
MLA
Sun, Y., Shao, H., Li, Z., Liu, J., Gao, L., Peng, X., Meng, Y., Li, W."ZNF268, a novel krüppel-like zinc finger protein, is implicated in early human liver development". International Journal of Molecular Medicine 14.6 (2004): 971-975.
Chicago
Sun, Y., Shao, H., Li, Z., Liu, J., Gao, L., Peng, X., Meng, Y., Li, W."ZNF268, a novel krüppel-like zinc finger protein, is implicated in early human liver development". International Journal of Molecular Medicine 14, no. 6 (2004): 971-975. https://doi.org/10.3892/ijmm.14.6.971