Cytoprotection by interleukin-6 against liver injury induced by lipopolysaccharide

  • Authors:
    • Ken-Ichiro Inoue
    • Hirohisa Takano
    • Akinori Shimada
    • Takehito Morita
    • Rie Yanagisawa
    • Miho Sakurai
    • Masahiko Sato
    • Shin Yoshino
    • Toshikazu Yoshikawa
  • View Affiliations

  • Published online on: Tuesday, February 1, 2005
  • Pages: 221-224
  • DOI: 10.3892/ijmm.15.2.221

Abstract

The role of interleukin (IL)-6 in inflammatory injury remains controversial. The present study elucidated the role of IL-6 in liver damage during severe inflammation induced by intraperitoneal administration of lipopolysaccharide (LPS; 1 mg/kg) using IL-6 null (-/-) mice and corresponding wild-type (WT) mice. Histological study showed that LPS treatment caused more severe liver injury with centrilobular vacuolation of hepatocytes and neutrophilic infiltration in the liver of IL-6 (-/-) mice; in contrast, neutrophilic infiltration and mild vacuolar change of hepatocytes were found in the liver of LPS-treated WT mice. Protein levels of proinflammatory molecules, such as IL-1β, macrophage inflammatory protein-1α, and macrophage chemoattractant protein-1, in the livers were significantly greater in IL-6 (-/-) mice than in WT mice after LPS challenge. These results directly indicate that IL-6 is protective against liver injury induced by bacterial endotoxin, at least partly, via the modulation of proinflammatory cytokines and chemokines
Journal Cover

February 2005
Volume 15 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Inoue, K., Takano, H., Shimada, A., Morita, T., Yanagisawa, R., Sakurai, M., Sato, M., Yoshino, S., & Yoshikawa, T. (2005). Cytoprotection by interleukin-6 against liver injury induced by lipopolysaccharide. International Journal of Molecular Medicine, 15(2), 221-224.
MLA
Inoue, Takano, Shimada, Morita, Yanagisawa, Sakurai, Sato, Yoshino, and Toshikazu Yoshikawa. "Cytoprotection by interleukin-6 against liver injury induced by lipopolysaccharide." International Journal of Molecular Medicine International Journal of Molecular Medicine 15.2 (2005): 221-224.
Chicago
Inoue, Takano, Shimada, Morita, Yanagisawa, Sakurai, Sato, Yoshino, and Toshikazu Yoshikawa. "Cytoprotection by interleukin-6 against liver injury induced by lipopolysaccharide." International Journal of Molecular Medicine International Journal of Molecular Medicine 15 no. 2 (2005): 221-224.