Melanin-concentrating hormone enhances sucrose intake

  • Authors: Ruka Sakamaki, Masaharu Uemoto, Akio Inui, Akihiro Asakawa, Naohiko Ueno, Chiyomi Ishibashi, Satoru Hirono, Hideo Yukioka, Akira Kato, Naotaka Shinfuku, Masato Kasuga, Goro Katsuura
  • View Affiliations

  • Published online on: Wednesday, June 1, 2005
  • Pages: 1033-1039
  • DOI: 10.3892/ijmm.15.6.1033

Abstract

Melanin-concentrating hormone (MCH) is known to be an important regulator for feeding and energy balance. MCH was recently reported to stimulate water intake independent of food intake. The purpose of the present study is to examine the dipsogenic response of MCH with special emphasis on sweetened beverages, the preference for which is well documented in diabetic animals. Our results showed that intracerebroventricular injection of MCH acutely increased food as well as water intake. Human (h)MCH and salmon (s)MCH increased water intake independent of food intake, which was not suppressed by angiotensin antagonists. hMCH and sMCH significantly increased both sucrose solution and food intake; on the other hand, agouti-related protein (AgRP) stimulated food but not sucrose intake when provided simultaneously. MCH-treated rats significantly increased the ingestion of sucrose and glucose solution, but not of saccharin, indicating that MCH-induced dipsogenic response is more related to caloric content than sweet taste per se. Significant correlation was observed between the sucrose intake and the mRNA expression of MCH and MCHR1 in normal rats. These results indicate that MCH may be an important regulator of sugar intake in normal as well as in obese diabetic animals.
Journal Cover

June 2005
Volume 15 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

2012 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Sakamaki, R., Uemoto, M., Inui, A., Asakawa, A., Ueno, N., Ishibashi, C., Hirono, S., Yukioka, H., Kato, A., Shinfuku, N., Kasuga, M., & Katsuura, G. (2005). Melanin-concentrating hormone enhances sucrose intake. International Journal of Molecular Medicine, 15(6), 1033-1039.
MLA
Sakamaki, Uemoto, Inui, Asakawa, Ueno, Ishibashi, Hirono, Yukioka, Kato, Shinfuku, Kasuga, and Goro Katsuura. "Melanin-concentrating hormone enhances sucrose intake." International Journal of Molecular Medicine International Journal of Molecular Medicine 15.6 (2005): 1033-1039.
Chicago
Sakamaki, Uemoto, Inui, Asakawa, Ueno, Ishibashi, Hirono, Yukioka, Kato, Shinfuku, Kasuga, and Goro Katsuura. "Melanin-concentrating hormone enhances sucrose intake." International Journal of Molecular Medicine International Journal of Molecular Medicine 15 no. 6 (2005): 1033-1039.