Anti-viral activity of human antithrombin III

  • Authors:
    • David R. Elmaleh
    • Nancy V. Brown
    • Ralf Geiben-Lynn
  • View Affiliations

  • Published online on: Monday, August 1, 2005
  • Pages: 191-200
  • DOI: 10.3892/ijmm.16.2.191

Abstract

Soluble inhibitory factors produced by CD8+ T-cells have been shown to inhibit HIV-1 replication and may play a critical role in vivo in anti-viral host defense. CD8+ T-cell-modified antithrombin III (ATIII) accounts for some of the described CD8+ T-cell anti-viral activity. We demonstrate that CD4+ T-cells, CD8+ T-cells, and natural killer cells react to an ATIII gradient by cell migration. Furthermore, exogenously added ATIII induced a G-protein-coupled signal transduction process in CD4+ T-cells and inhibited TNF-α-induced NF-κB activation. Heat and/or heparin treatment prior to the anti-viral inhibition test increased the anti-HIV activity up to 1000-fold. Our data indicate that anti-viral inactive ATIII can be activated having promising anti-viral properties as complementary candidate for the treatment of HIV infection.
Journal Cover

August 2005
Volume 16 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Elmaleh, D., Brown, N., & Geiben-Lynn, R. (2005). Anti-viral activity of human antithrombin III. International Journal of Molecular Medicine, 16(2), 191-200.
MLA
Elmaleh, Brown, and Ralf Geiben-Lynn. "Anti-viral activity of human antithrombin III." International Journal of Molecular Medicine International Journal of Molecular Medicine 16.2 (2005): 191-200.
Chicago
Elmaleh, Brown, and Ralf Geiben-Lynn. "Anti-viral activity of human antithrombin III." International Journal of Molecular Medicine International Journal of Molecular Medicine 16 no. 2 (2005): 191-200.