Long-term follow-up of Japanese patients with chronic hepatitis B treated with interferon-α

  • Authors: Bui Xuan Truong, Yasushi Seo, Miyuki Kato, Kenichi Hamano, Toshiaki Ninomiya, Megumi Katayama, Hirotaka Kato, Yoshihiko Yano, Yoshitake Hayashi, Masato Kasuga
  • View Affiliations

  • Published online on: Monday, August 1, 2005
  • Pages: 279-284
  • DOI: 10.3892/ijmm.16.2.279

Abstract

The long-term usefulness of interferon-alpha (IFN-α) in chronic hepatitis B remains controversial. To investigate the long-term efficacy of IFN-α therapy in chronic hepatitis B, 62 Japanese patients, including 27 patients treated with IFN-α (IFN group) and 35 patients without antiviral therapy matched by age and sex as controls (control group), were followed up for 2-14 years. At entry, the serum alanine aminotransferase (ALT) level in the IFN group was significantly higher than that in the control group (238.6±250.1 vs. 142.3±152.1 IU/l, P<0.05). The prevalence of genotype C was 89%, with no difference between the two groups (93 vs. 86%). There was no significant difference in the presence of the precore mutation or the dual core promoter mutations between the IFN and control groups (37 vs. 46%, 74 vs. 66%). After long-term follow-up, the rate of sustained HBeAg seroconversion was comparable in the two groups (33 vs. 31%). Normalization of serum ALT level was seen in 44% of the IFN group and 51% of the control group, with no difference. There was also no difference in the percentage of cases with loss of serum HBV-DNA by PCR assay between the two groups (33 vs. 29%). During follow-up, two patients of the control group and three patients of the IFN group developed cirrhosis, and one of the IFN- treated patients progressed to hepatocellular carcinoma. The results of this long-term follow-up study showed that no benefit of IFN-α treatment was detectable during long-term follow-up in Japanese patients with chronic hepatitis B.
Journal Cover

August 2005
Volume 16 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

2012 Impact Factor: 1.957
Ranked #26/121 Medicine Research and Experimental
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APA
Truong, B., Seo, Y., Kato, M., Hamano, K., Ninomiya, T., Katayama, M., Kato, H., Yano, Y., Hayashi, Y., & Kasuga, M. (2005). Long-term follow-up of Japanese patients with chronic hepatitis B treated with interferon-α. International Journal of Molecular Medicine, 16(2), 279-284.
MLA
Truong, Seo, Kato, Hamano, Ninomiya, Katayama, Kato, Yano, Hayashi, and Masato Kasuga. "Long-term follow-up of Japanese patients with chronic hepatitis B treated with interferon-α." International Journal of Molecular Medicine International Journal of Molecular Medicine 16.2 (2005): 279-284.
Chicago
Truong, Seo, Kato, Hamano, Ninomiya, Katayama, Kato, Yano, Hayashi, and Masato Kasuga. "Long-term follow-up of Japanese patients with chronic hepatitis B treated with interferon-α." International Journal of Molecular Medicine International Journal of Molecular Medicine 16 no. 2 (2005): 279-284.