Age-dependent decrease in the ghrelin gene expression in the human adrenal cortex: A real-time PCR study

  • Authors: Gianni Carraro, Giovanna Albertin, Francesco Aragona, Myriam Forneris, Valentina Casale, Raffaella Spinazzi, Gastone G. Nussdorfer
  • View Affiliations

  • Published online on: Wednesday, February 1, 2006
  • Pages: 319-321
  • DOI: 10.3892/ijmm.17.2.319

Abstract

Numerous lines of evidence indicate that ghrelin, an endogenous ligand of the growth hormone-secretagogue receptor, is expressed in the human and rat adrenal cortex. In this study, we examined whether ghrelin gene expression undergoes changes in the human adrenal cortex during aging. Semi-quantitative real-time reverse transcription-polymerase chain reaction demonstrated a highly significant negative correlation between ghrelin mRNA and age in adrenal cortexes of 27 patients (aged from 33 to 82 years), who underwent unilateral adrenalectomy/nephrectomy for kidney cancer. No significant differences in the level of adrenal ghrelin expression were observed between males and females. Since it has been previously shown that ghrelin exerts a marked growth-stimulating action on cultured adrenocortical cells, we hypothesize that the down-regulation of ghrelin gene transcription in adrenals could be associated with the reported decrease in adrenal DNA synthesis and mitogenic activity during aging.
Journal Cover

February 2006
Volume 17 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

2012 Impact Factor: 1.957
Ranked #26/121 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Carraro, G., Albertin, G., Aragona, F., Forneris, M., Casale, V., Spinazzi, R., & Nussdorfer, G. (2006). Age-dependent decrease in the ghrelin gene expression in the human adrenal cortex: A real-time PCR study. International Journal of Molecular Medicine, 17(2), 319-321.
MLA
Carraro, Albertin, Aragona, Forneris, Casale, Spinazzi, and Gastone Nussdorfer. "Age-dependent decrease in the ghrelin gene expression in the human adrenal cortex: A real-time PCR study." International Journal of Molecular Medicine International Journal of Molecular Medicine 17.2 (2006): 319-321.
Chicago
Carraro, Albertin, Aragona, Forneris, Casale, Spinazzi, and Gastone Nussdorfer. "Age-dependent decrease in the ghrelin gene expression in the human adrenal cortex: A real-time PCR study." International Journal of Molecular Medicine International Journal of Molecular Medicine 17 no. 2 (2006): 319-321.