Apoptotic-inducing activity of novel polycyclic aromatic compounds in human leukemic cells

  • Authors:
    • Kristin R. Landis-Piwowar
    • Di Chen
    • Qiuzhi Cindy Cui
    • Vesna Minic
    • Frederick F. Becker
    • Bimal K. Banik
    • Q. Ping Dou
  • View Affiliations

  • Published online on: May 1, 2006     https://doi.org/10.3892/ijmm.17.5.931
  • Pages: 931-935
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Abstract

Persistent but relatively limited research has been devoted to the use of compounds related to polycyclic aromatic hydrocarbons (PAH) as anticancer agents. In previous reports, we have described the cytotoxicity of a number of new and novel PAH against human cancer cell lines. However, the involved molecular mechanisms of inducing cell death were not elucidated. In the current study, we describe the apoptotic pathway as apparently playing a crucial role in induced cell death in human leukemia Jurkat T cells by several diamide and diamine PAH that contain chrysene as their core aromatic ring system. Structure-activity relationships were analyzed. Importantly, no effect was demonstrated in a normal, non-transformed line of human natural killer cells. These results provide additional evidence for the potential chemotherapeutic use of PAH.

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May 2006
Volume 17 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Landis-Piwowar KR, Chen D, Cui QC, Minic V, Becker FF, Banik BK and Dou QP: Apoptotic-inducing activity of novel polycyclic aromatic compounds in human leukemic cells. Int J Mol Med 17: 931-935, 2006.
APA
Landis-Piwowar, K.R., Chen, D., Cui, Q.C., Minic, V., Becker, F.F., Banik, B.K., & Dou, Q.P. (2006). Apoptotic-inducing activity of novel polycyclic aromatic compounds in human leukemic cells. International Journal of Molecular Medicine, 17, 931-935. https://doi.org/10.3892/ijmm.17.5.931
MLA
Landis-Piwowar, K. R., Chen, D., Cui, Q. C., Minic, V., Becker, F. F., Banik, B. K., Dou, Q. P."Apoptotic-inducing activity of novel polycyclic aromatic compounds in human leukemic cells". International Journal of Molecular Medicine 17.5 (2006): 931-935.
Chicago
Landis-Piwowar, K. R., Chen, D., Cui, Q. C., Minic, V., Becker, F. F., Banik, B. K., Dou, Q. P."Apoptotic-inducing activity of novel polycyclic aromatic compounds in human leukemic cells". International Journal of Molecular Medicine 17, no. 5 (2006): 931-935. https://doi.org/10.3892/ijmm.17.5.931