Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals

  • Authors:
    • Yoshiji Yamada
    • Fujiko Ando
    • Hiroshi Shimokata
  • View Affiliations

  • Published online on: July 1, 2006     https://doi.org/10.3892/ijmm.18.1.119
  • Pages: 119-127
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Abstract

Evidence suggests the existence of a close relation between lipid metabolism and bone remodeling. We hypo-thesized that polymorphisms of genes that play a role in lipid metabolism, such as those for forkhead box C2 (FOXC2) and perilipin (PLIN), might affect bone mineral density (BMD). We thus examined the possible relationships between a -512C↷T polymorphism of FOXC2 and a 1243C↷T polymorphism of PLIN to BMD in community-dwelling Japanese women and men. The subjects (1129 men, 1114 women for FOXC2; 1122 men, 1112 women for PLIN) were aged 40 to 79 years and were randomly recruited to a population-based prospective cohort study of aging and age-related diseases in Japan. Genotypes for FOXC2 and PLIN were determined with a fluorescence-based allele-specific DNA primer assay system. The -512C↷T polymorphism of FOXC2 was associated with BMD for the distal and proximal radius in men and in premenopausal women as well as with BMD for the distal radius and total body in postmenopausal women, with the T allele being related to reduced BMD. The 1243C↷T polymorphism of PLIN was associated with BMD for the total body, lumbar spine, femoral neck, and trochanter in men, with the C allele being related to reduced BMD. This polymorphism of PLIN was not associated with BMD in all women. These results suggest that FOXC2 is a susceptibility locus for reduced BMD in Japanese men and women, and that PLIN constitutes such a locus in Japanese men.

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July 2006
Volume 18 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yamada Y, Ando F and Shimokata H: Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals. Int J Mol Med 18: 119-127, 2006.
APA
Yamada, Y., Ando, F., & Shimokata, H. (2006). Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals. International Journal of Molecular Medicine, 18, 119-127. https://doi.org/10.3892/ijmm.18.1.119
MLA
Yamada, Y., Ando, F., Shimokata, H."Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals". International Journal of Molecular Medicine 18.1 (2006): 119-127.
Chicago
Yamada, Y., Ando, F., Shimokata, H."Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals". International Journal of Molecular Medicine 18, no. 1 (2006): 119-127. https://doi.org/10.3892/ijmm.18.1.119