Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat

  • Authors: Witold Malendowicz, Marcin Rucinski, Carlo Macchi, Raffaella Spinazzi, Agnieszka Ziolkowska, Gastone G. Nussdorfer, Zbigniew Kwias
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  • Published online on: Sunday, October 1, 2006
  • Pages: 615-618
  • DOI: 10.3892/ijmm.18.4.615

Abstract

Leptin is an adipose tissue-secreted hormone that acts via specific receptors (Ob-R), of which six isoforms are at present recognized (from Ob-Ra to Ob-Rf). Ob-Rb is the only isoform able to activate JAK-STAT and MAPK signaling cascades. A large body of evidence suggests that leptin and its receptors are involved in prostate physiology and pathophysiology in humans, but studies on the leptin system in the rat prostate are lacking. Reverse transcription-polymerase chain reaction showed the expression of mRNAs of leptin, Ob-Ra, Ob-Rb, Ob-Rc, Ob-Re and Ob-Rf in adult rat seminal vesicles and prostate (coagulating, dorsal, ventral and lateral lobes). Western blotting demonstrated the presence in these specimens of the Ob-Rb protein, and immunocytochemistry revealed that Ob-Rb was mainly located in their epithelial-cell component. Collectively, these findings strongly suggest that leptin and Ob-R may be involved in the autocrine-paracrine functional regulation of the epithelial cells of adult rat seminal vesicles and prostate.
Journal Cover

October 2006
Volume 18 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
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APA
Malendowicz, W., Rucinski, M., Macchi, C., Spinazzi, R., Ziolkowska, A., Nussdorfer, G., & Kwias, Z. (2006). Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat. International Journal of Molecular Medicine, 18(4), 615-618.
MLA
Malendowicz, Rucinski, Macchi, Spinazzi, Ziolkowska, Nussdorfer, and Zbigniew Kwias. "Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat." International Journal of Molecular Medicine International Journal of Molecular Medicine 18.4 (2006): 615-618.
Chicago
Malendowicz, Rucinski, Macchi, Spinazzi, Ziolkowska, Nussdorfer, and Zbigniew Kwias. "Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat." International Journal of Molecular Medicine International Journal of Molecular Medicine 18 no. 4 (2006): 615-618.