Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus

  • Authors:
    • Sachiyo Yamaguchi
    • Yoshiji Yamada
    • Hitoshi Matsuo
    • Tomonori Segawa
    • Sachiro Watanabe
    • Kimihiko Kato
    • Kiyoshi Yokoi
    • Sahoko Ichihara
    • Norifumi Metoki
    • Hidemi Yoshida
    • Kei Satoh
    • Yoshinori Nozawa
  • Corresponding author:
  • View Affiliations

  • Published online on: Sunday, April 1, 2007
  • Pages: 631-637 DOI: 10.3892/ijmm.19.4.631

Abstract

Type 2 diabetes mellitus is a complex metabolic disorder in which endogenous sex hormones may contribute to sex-dependent etiologies. We hypothesized that genetic variants related to type 2 diabetes mellitus might differ between men and women. We thus performed a large-scale association study to identify gene polymorphisms associated with type 2 diabetes mellitus in men and women separately. The study population comprised 4854 unrelated Japanese individuals (2688 men, 2166 women), including 1490 subjects with type 2 diabetes mellitus (969 men, 521 women). The genotypes for 16 gene polymorphisms were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Multivariable logistic regression analysis with adjustment for age, body mass index, and smoking status revealed that the T↷G (3' UTR) polymorphism of the thrombospondin 2 gene (THBS2), the -603A↷G polymorphism of the coagulation factor III gene (F3), and the G↷T (intron 2) polymorphism of the adipocyte, C1Q, and collagen domain containing (adiponectin) gene (ADIPOQ) were significantly associated with the prevalence of type 2 diabetes mellitus in men, and that the A↷G (Arg160Gly) polymorphism of the paraoxonase 1 gene (PON1) was significantly associated with this condition in women. A stepwise forward selection procedure demonstrated that genotypes of THBS2, F3, and ADIPOQ were significant determinants of type 2 diabetes mellitus in men, and that genotype of PON1 significantly affected this condition in women. Genotyping of these polymorphisms may prove informative for assessment of the genetic component of type 2 diabetes mellitus for men and women separately.
Journal Cover

April 2007
Volume 19 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
2014 I.F. (Expected) ≥ 2.372 Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Yamaguchi, S., Yamada, Y., Matsuo, H., Segawa, T., Watanabe, S., Kato, K. ... Nozawa, Y. (2007). Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus. International Journal of Molecular Medicine, 19, 631-637. http://dx.doi.org/10.3892/ijmm.19.4.631
MLA
Yamaguchi, S., Yamada, Y., Matsuo, H., Segawa, T., Watanabe, S., Kato, K., Yokoi, K., Ichihara, S., Metoki, N., Yoshida, H., Satoh, K., Nozawa, Y."Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus". International Journal of Molecular Medicine 19.4 (2007): 631-637.
Chicago
Yamaguchi, S., Yamada, Y., Matsuo, H., Segawa, T., Watanabe, S., Kato, K., Yokoi, K., Ichihara, S., Metoki, N., Yoshida, H., Satoh, K., Nozawa, Y."Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus". International Journal of Molecular Medicine 19, no. 4 (2007): 631-637. http://dx.doi.org/10.3892/ijmm.19.4.631