Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus

  • Authors:
    • Sachiyo Yamaguchi
    • Yoshiji Yamada
    • Hitoshi Matsuo
    • Tomonori Segawa
    • Sachiro Watanabe
    • Kimihiko Kato
    • Kiyoshi Yokoi
    • Sahoko Ichihara
    • Norifumi Metoki
    • Hidemi Yoshida
    • Kei Satoh
    • Yoshinori Nozawa
  • View Affiliations

  • Published online on: Sunday, April 1, 2007
  • Pages: 631-637
  • DOI: 10.3892/ijmm.19.4.631

Abstract

Type 2 diabetes mellitus is a complex metabolic disorder in which endogenous sex hormones may contribute to sex-dependent etiologies. We hypothesized that genetic variants related to type 2 diabetes mellitus might differ between men and women. We thus performed a large-scale association study to identify gene polymorphisms associated with type 2 diabetes mellitus in men and women separately. The study population comprised 4854 unrelated Japanese individuals (2688 men, 2166 women), including 1490 subjects with type 2 diabetes mellitus (969 men, 521 women). The genotypes for 16 gene polymorphisms were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Multivariable logistic regression analysis with adjustment for age, body mass index, and smoking status revealed that the T↷G (3' UTR) polymorphism of the thrombospondin 2 gene (THBS2), the -603A↷G polymorphism of the coagulation factor III gene (F3), and the G↷T (intron 2) polymorphism of the adipocyte, C1Q, and collagen domain containing (adiponectin) gene (ADIPOQ) were significantly associated with the prevalence of type 2 diabetes mellitus in men, and that the A↷G (Arg160Gly) polymorphism of the paraoxonase 1 gene (PON1) was significantly associated with this condition in women. A stepwise forward selection procedure demonstrated that genotypes of THBS2, F3, and ADIPOQ were significant determinants of type 2 diabetes mellitus in men, and that genotype of PON1 significantly affected this condition in women. Genotyping of these polymorphisms may prove informative for assessment of the genetic component of type 2 diabetes mellitus for men and women separately.
Journal Cover

April 2007
Volume 19 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Yamaguchi, S., Yamada, Y., Matsuo, H., Segawa, T., Watanabe, S., Kato, K., Yokoi, K., Ichihara, S., Metoki, N., Yoshida, H., Satoh, K., & Nozawa, Y. (2007). Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus. International Journal of Molecular Medicine, 19(4), 631-637.
MLA
Yamaguchi, Yamada, Matsuo, Segawa, Watanabe, Kato, Yokoi, Ichihara, Metoki, Yoshida, Satoh, and Yoshinori Nozawa. "Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus." International Journal of Molecular Medicine International Journal of Molecular Medicine 19.4 (2007): 631-637.
Chicago
Yamaguchi, Yamada, Matsuo, Segawa, Watanabe, Kato, Yokoi, Ichihara, Metoki, Yoshida, Satoh, and Yoshinori Nozawa. "Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus." International Journal of Molecular Medicine International Journal of Molecular Medicine 19 no. 4 (2007): 631-637.