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8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.

  • Authors:
    • K Igarashi
    • T Isohara
    • T Kato
    • K Takigawa
    • K Shigeta
    • T Yamano
    • I Uno

  • View Affiliations

  • Published online on: August 1, 1998     https://doi.org/10.3892/ijmm.2.2.211
  • Pages: 211-426
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Angiogenesis is regulated by various factors. In particular, VEGF and basic FGF are of much importance. We found that 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibited the binding of VEGF to KDR/Flk-1 (VEGF receptor-2) or Flt-1 (VEGF receptor-1) and that it inhibited the MAPK phosphorylation in HUVEC induced by VEGF or basic FGF but not by EGF. 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid might be used as an inhibitor of VEGF and basic FGF signal transduction.

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Journal Cover

Aug 1998
Volume 2 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Igarashi K, Isohara T, Kato T, Takigawa K, Shigeta K, Yamano T and Uno I: 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.. Int J Mol Med 2: 211-426, 1998
APA
Igarashi, K., Isohara, T., Kato, T., Takigawa, K., Shigeta, K., Yamano, T., & Uno, I. (1998). 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.. International Journal of Molecular Medicine, 2, 211-426. https://doi.org/10.3892/ijmm.2.2.211
MLA
Igarashi, K., Isohara, T., Kato, T., Takigawa, K., Shigeta, K., Yamano, T., Uno, I."8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.". International Journal of Molecular Medicine 2.2 (1998): 211-426.
Chicago
Igarashi, K., Isohara, T., Kato, T., Takigawa, K., Shigeta, K., Yamano, T., Uno, I."8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.". International Journal of Molecular Medicine 2, no. 2 (1998): 211-426. https://doi.org/10.3892/ijmm.2.2.211