| Novel effect of estrogen on RANK and c-fms expression in RAW 264.7 cells |
Authors: Nadia Galal, Waleed R. El-Beialy, Yoshiaki Deyama, Yoshitaka Yoshimura, Kuniaki Suzuki, Yasunori Totsuka |
Affiliations:
Department of Oral and Maxillofacial Surgery, Hokkaido University Graduate School of Dental Medicine, Hokkaido, Japan
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Pages: 97-101 |
Abstract:
Temporomandibular disorder (TMD), a progressive disease entity, and osteoarthrosis preferentially affect females, denoting a possible role of estrogen. Using RAW 264.7 cells, the expression of estrogen receptors (ERs) α and β and the consequent effect of estrogen was investigated. We present the novel detection of ER β expression in RAW 264.7 cells. Furthermore, we innovatively demonstrated the increase in expression of both ER α and β, as well as RANK and c-fms, with estrogen treatment. However, a decrease in expression of c-fms, RANK and ER β, and nearly no change in the expression of ER α were experienced upon further increase in estrogen concentrations. These findings lead us to hypothesize a new mechanism of inflammation in TMD.
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