Inflammatory status in patients with chronic renal failure: The role of PTX3 and pro-inflammatory cytokines

  • Authors:
    • Grazia Malaponte
    • Massimo Libra
    • Ylenia Bevelacqua
    • Paola Merito
    • Pasquale Fatuzzo
    • Francesco Rapisarda
    • Maria Cristina
    • Gabriele Naselli
    • Franca Stivala
    • Maria C. Mazzarino
    • Pietro Castellino
  • View Affiliations

  • Published online on: October 1, 2007     https://doi.org/10.3892/ijmm.20.4.471
  • Pages: 471-481
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Abstract

Increased plasma levels of several acute phase proteins, such as C-reactive protein (CRP), have been documented among different patients with chronic renal failure (CRF). The aim of the present study was to determine whether pentraxin-3 (PTX3) is a reliable marker of inflammation in CRF. Plasma samples and monocytes were taken from 43 patients before and after undergoing haemodialysis (HD), from 45 uraemic patients (UR) without HD treatment and from 25 healthy controls. Plasma and monocyte samples were analyzed by ELISA for levels of PTX3, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6); all of these protein levels were higher in CRF patients with respect to the controls. After HD, plasma PTX3 and cytokine levels increased. Inter- and intra-individual variations in CRP were observed in HD patients, while PTX3 plasma levels were stable. Release of PTX3, TNF-α, IL-1β and IL-6 by unstimulated monocytes from patients, before and after HD, was higher with respect to UR patients and controls. After lipopolysaccharide stimulation, all values were higher in patients before HD than those in UR patients, but lower when compared to those in the controls. In contrast, no changes were observed after HD. A significant correlation among plasma PTX3 versus fibrinogen, TNF-α and IL-1β was observed in HD and UR patients. Collectively, these data suggest that PTX3 protein may represent an additional and stable marker of inflammation in CRF.

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October 2007
Volume 20 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Malaponte G, Libra M, Bevelacqua Y, Merito P, Fatuzzo P, Rapisarda F, Cristina M, Naselli G, Stivala F, Mazzarino MC, Mazzarino MC, et al: Inflammatory status in patients with chronic renal failure: The role of PTX3 and pro-inflammatory cytokines. Int J Mol Med 20: 471-481, 2007
APA
Malaponte, G., Libra, M., Bevelacqua, Y., Merito, P., Fatuzzo, P., Rapisarda, F. ... Castellino, P. (2007). Inflammatory status in patients with chronic renal failure: The role of PTX3 and pro-inflammatory cytokines. International Journal of Molecular Medicine, 20, 471-481. https://doi.org/10.3892/ijmm.20.4.471
MLA
Malaponte, G., Libra, M., Bevelacqua, Y., Merito, P., Fatuzzo, P., Rapisarda, F., Cristina, M., Naselli, G., Stivala, F., Mazzarino, M. C., Castellino, P."Inflammatory status in patients with chronic renal failure: The role of PTX3 and pro-inflammatory cytokines". International Journal of Molecular Medicine 20.4 (2007): 471-481.
Chicago
Malaponte, G., Libra, M., Bevelacqua, Y., Merito, P., Fatuzzo, P., Rapisarda, F., Cristina, M., Naselli, G., Stivala, F., Mazzarino, M. C., Castellino, P."Inflammatory status in patients with chronic renal failure: The role of PTX3 and pro-inflammatory cytokines". International Journal of Molecular Medicine 20, no. 4 (2007): 471-481. https://doi.org/10.3892/ijmm.20.4.471