Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency

  • Authors:
    • Rong Jin
    • Hideo Kaneko
    • Hiroko Suzuki
    • Takahiro Arai
    • Takahide Teramoto
    • Toshiyuki Fukao
    • Naomi Kondo
  • View Affiliations

  • Published online on: February 1, 2008     https://doi.org/10.3892/ijmm.21.2.233
  • Pages: 233-238
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Abstract

In some patients with common variable immunodeficiency (CVID) and immunoglobulin (Ig) A deficiency (IgAD), tumor necrosis factor (TNF) family receptor transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) gene mutations have been reported. B cells from individuals with TACI mutations do not produce IgG and IgA in response to the TACI ligand a proliferation-inducing ligand (APRIL) which probably suggests impaired isotype switching. To clarify the pathogenesis of CVID and IgAD of Japanese patients, we investigated the mutations of TNF family members TACI, APRIL, B-cell activating factor (BAFF), B-cell maturation antigen (BCMA) and BAFF receptor (BAFF-R) genes and the expression levels of BAFF and APRIL in patients with CVID, IgAD and X-linked agammaglobulinaemia (XLA). We also investigated the relationship between age and the blood plasma levels of BAFF and APRIL. The causative gene mutations of TNF family members in our patients were not detected. In healthy subjects, the BAFF and APRIL plasma levels correlated inversely with age. The BAFF and APRIL plasma levels of patients with CVID, IgAD and XLA were significantly higher than those of healthy children. Elevated BAFF and APRIL expression levels might partially reflect the common immunological feature of primary antibody deficiency.

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February 2008
Volume 21 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Jin R, Kaneko H, Suzuki H, Arai T, Teramoto T, Fukao T and Kondo N: Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. Int J Mol Med 21: 233-238, 2008
APA
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., & Kondo, N. (2008). Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency. International Journal of Molecular Medicine, 21, 233-238. https://doi.org/10.3892/ijmm.21.2.233
MLA
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., Kondo, N."Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency". International Journal of Molecular Medicine 21.2 (2008): 233-238.
Chicago
Jin, R., Kaneko, H., Suzuki, H., Arai, T., Teramoto, T., Fukao, T., Kondo, N."Age-related changes in BAFF and APRIL profiles and upregulation of BAFF and APRIL expression in patients with primary antibody deficiency". International Journal of Molecular Medicine 21, no. 2 (2008): 233-238. https://doi.org/10.3892/ijmm.21.2.233