Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)

  • Authors: Faizeh Al-Quobaili, Mathias Montenarh
  • View Affiliations

  • Published online on: Tuesday, April 1, 2008
  • Pages: 399-404
  • DOI: 10.3892/ijmm.21.4.399

Abstract

The homeobox domain transcription factor PDX-1 is essential for pancreatic development and for the maintenance of β-cell function. The participation of pancreatic duodenal homeobox factor-1 (PDX-1) in the transcription of several genes which are essential for glucose sensing and insulin synthesis underlines its key role in β-cells of the pancreas. PDX-1 binds to the promoter of insulin, glucose transporter 2, and glucokinase and regulates their expression. By protein-protein interaction, PDX-1 acts in concert with other transcription factors or coactivators at the level of the insulin promoter. Ectopic expression of PDX-1 together with other cofactors can re-program cells to behave like β-cells and produce insulin. This property of PDX-1 opens new strategies for the treatment of diabetes. Little is known about its regulation at the posttranslational level. Here, we report on its DNA-binding activity, the nuclear import and on post-translational modifications such as phosphorylation, glycosylation and sumoylation. Modulation of these post-translational modifications may be an alternate strategy for treating diabetes.
Journal Cover

April 2008
Volume 21 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2012 Impact Factor: 1.957
Ranked #26/121 Medicine Research and Experimental
(total number of cites)

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APA
Al-Quobaili, F., & Montenarh, M. (2008). Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review). International Journal of Molecular Medicine, 21(4), 399-404.
MLA
Al-Quobaili, and Mathias Montenarh. "Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)." International Journal of Molecular Medicine International Journal of Molecular Medicine 21.4 (2008): 399-404.
Chicago
Al-Quobaili, and Mathias Montenarh. "Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)." International Journal of Molecular Medicine International Journal of Molecular Medicine 21 no. 4 (2008): 399-404.