Molecular mapping of Factor XIIIa-enriched dendrocytes in the skin (Review)

  • Authors: Pascale Quatresooz, Philippe Paquet, Trinh Hermanns-Lê, Gérald E. Piérard
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  • Published online on: Wednesday, October 1, 2008
  • Pages: 403-409
  • DOI: 10.3892/ijmm_00000036

Abstract

The human dermis contains a series of dendritic cells which express different phenotypes including Factor XIIIa immunoreactivity. This compound is related to a blood coagulation factor participating in angiogenesis, in the final stages of the clotting cascade and in wound healing. In normal skin, Factor XIIIa is expressed in specific dermal dendrocytes (DD) derived from the monocyte/macrophage lineage or from a mesenchymal origin. DD are located predominantly around the microvasculature in the adventitial dermis, at the dermo-epidermal junction, and around skin appendages, but normally not within the epidermis. Increased numbers of Factor XIIIa+ DD are present in a host of specific cutaneous inflammatory and fibrotic conditions. In tumor pathology, immunophenotypic differences are found between dermatofibromas and other fibrohistiocytic entities, most notably dermatofibrosarcoma protuberans. In addition, Factor XIIIa+ DD are likely to be involved in the progression and regression of some malignancies including cutaneous melanoma and basal cell carcinoma.
Journal Cover

October 2008
Volume 22 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Quatresooz, P., Paquet, P., Hermanns-Lê, T., & Piérard, G. (2008). Molecular mapping of Factor XIIIa-enriched dendrocytes in the skin (Review). International Journal of Molecular Medicine, 22(4), 403-409.
MLA
Quatresooz, Paquet, Hermanns-Lê, and Gérald Piérard. "Molecular mapping of Factor XIIIa-enriched dendrocytes in the skin (Review)." International Journal of Molecular Medicine International Journal of Molecular Medicine 22.4 (2008): 403-409.
Chicago
Quatresooz, Paquet, Hermanns-Lê, and Gérald Piérard. "Molecular mapping of Factor XIIIa-enriched dendrocytes in the skin (Review)." International Journal of Molecular Medicine International Journal of Molecular Medicine 22 no. 4 (2008): 403-409.