Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo

  • Authors: Jae-We Cho, Sun-Young Cho, Seong-Ryong Lee, Kyu-Suk Lee
  • View Affiliations

  • Published online on: Monday, March 1, 2010
  • Pages: 347-352
  • DOI: 10.3892/ijmm_00000351

Abstract

A scar is usually developed by an imbalance of collagen synthesis and degradation. It is believed that the flavonoids (quercetin and kaempferol) in onion extract play a role in reducing scar formation through inhibition of fibroblast activities. Even though several commercial products are composed of onion extract, the precise molecular mechanisms of onion extract in reduction of scar formation in skin are still largely unknown. In this study we investigated the effect both of onion extract and quercetin on the proliferation of fibroblasts, expression of type I collagen and matrix metalloproteinase-1 (MMP-1). Our data show that proliferation rates of fibroblasts were decreased in a dose-dependent manner of the onion extract and quercetin. The expression of type I collagen was not markedly changed by the onion extract and quercetin. Interestingly, the expression of MMP-1 was markedly increased by both onion extract and quercetin in vitro and in vivo. Thus, our data indicate that onion extract and quercetin play a role in the anti-scar effect in skin through up-regulation of MMP-1 expression, implying this agent is a promising material for reducing scar formation.
Journal Cover

March 2010
Volume 25 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Cho, J., Cho, S., Lee, S., & Lee, K. (2010). Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo. International Journal of Molecular Medicine, 25(3), 347-352.
MLA
Cho, Cho, Lee, and Kyu-Suk Lee. "Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo." International Journal of Molecular Medicine International Journal of Molecular Medicine 25.3 (2010): 347-352.
Chicago
Cho, Cho, Lee, and Kyu-Suk Lee. "Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo." International Journal of Molecular Medicine International Journal of Molecular Medicine 25 no. 3 (2010): 347-352.