Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice

  • Authors: Andrej Jedinak, Shailesh Dudhgaonkar, Jiahua Jiang, George Sandusky, Daniel Sliva
  • View Affiliations

  • Published online on: Monday, November 1, 2010
  • Pages: 643-650
  • DOI: 10.3892/ijmm_00000509

Abstract

Colorectal cancer is one of the leading causes of cancer deaths in both men and women in the world. However, colon cancer can be prevented to some extent by consumption of edible natural products with chemopreventive properties. Therefore, we investigated, whether edible mushroom Pleurotus ostreatus (PO) has chemopreventive effect on inflammation-associated colon carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and promoted by dextran sodium sulfate (DSS). PO treatment, at both doses (100 and 500 mg/kg), significantly reduced by 50 and 78% the number of aberrant crypt foci and the multiplicity of colon neoplasms by 43 and 89%, respectively. However, incidence of colon tumors and high grade dysplasia was reduced by 50 and 63% only in the dose 500 mg/kg of PO, respectively. Colon shortening and dysplastic index was significantly reduced by PO treatment in dose-dependent manner. The immunohistochemistry of colons revealed that treatment with PO suppressed expression of cyclin D1, Ki-67, COX-2 and F4/80. In summary, our data suggest that PO may prevent inflammation-associated colon carcinogenesis with exposure to PhIP through combined modulatory mechanisms of inflammation and tumor growth via suppression of COX-2, F4/80, Ki-67 and cyclin D1 expression in mice.
Journal Cover

November 2010
Volume 26 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Jedinak, A., Dudhgaonkar, S., Jiang, J., Sandusky, G., & Sliva, D. (2010). Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice . International Journal of Molecular Medicine, 26(5), 643-650.
MLA
Jedinak, Dudhgaonkar, Jiang, Sandusky, and Daniel Sliva. "Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice ." International Journal of Molecular Medicine International Journal of Molecular Medicine 26.5 (2010): 643-650.
Chicago
Jedinak, Dudhgaonkar, Jiang, Sandusky, and Daniel Sliva. "Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice ." International Journal of Molecular Medicine International Journal of Molecular Medicine 26 no. 5 (2010): 643-650.