Association study of +45G15G(T/G) and +276(G/T) polymorphisms in the adiponectin gene in patients with polycystic ovary syndrome

  • Authors: Lan Li, Ji-Hyun Yun, Jae-Hyun Lee, Sangjin Song, Bum-Chae Choi, Kwang-Hyun Baek
  • View Affiliations

  • Published online on: Wednesday, December 1, 2010
  • Pages: 283-287
  • DOI: 10.3892/ijmm.2010.565

Abstract

The polycystic ovary syndrome (PCOS) is considered as one of the most common endocrine and reproductive dysfunctional diseases. Recent research for genetic variants has identified genetic influences between the polymorphisms of the adiponectin gene and the metabolic syndromes. The aim of our study was to investigate the relationship between single nucleotide polymorphisms (SNPs) in the adiponectin gene and PCOS. Two SNPs, +45G15G(T/G) and +276(G/T), which are found in exon 2 and intron 2, respectively, of the adiponectin gene, were genotyped by PCR-RFLP. Out of 303 women studied for the +45G15G(T/G) and +276(G/T) SNPs, 144 had PCOS and 159 were healthy controls. No association was found between the +45(T/G) SNP and PCOS (P=0.3558, OR=0.83, 95% confidence interval), per contra to the association between +276(G/T) SNP and PCOS (P=0.0126, OR=0.60, 95% confidence interval). These results indicate that the SNP of +276(G/T) is strongly associated with PCOS. However, the +45(T/G) SNP is not associated with PCOS.
Journal Cover

February 2011
Volume 27 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
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APA
Li, L., Yun, J., Lee, J., Song, S., Choi, B., & Baek, K. (2011). Association study of +45G15G(T/G) and +276(G/T) polymorphisms in the adiponectin gene in patients with polycystic ovary syndrome. International Journal of Molecular Medicine, 27(2), 283-287.
MLA
Li, Yun, Lee, Song, Choi, and Kwang-Hyun Baek. "Association study of +45G15G(T/G) and +276(G/T) polymorphisms in the adiponectin gene in patients with polycystic ovary syndrome." International Journal of Molecular Medicine International Journal of Molecular Medicine 27.2 (2011): 283-287.
Chicago
Li, Yun, Lee, Song, Choi, and Kwang-Hyun Baek. "Association study of +45G15G(T/G) and +276(G/T) polymorphisms in the adiponectin gene in patients with polycystic ovary syndrome." International Journal of Molecular Medicine International Journal of Molecular Medicine 27 no. 2 (2011): 283-287.