Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions

  • Authors:
    • Chul-Hong Park
    • Dong-Yoon Nam
    • Hyeong-U Son
    • Si-Rim Lee
    • Hyun-Jin Lee
    • Jin-Chul Heo
    • Tae-Yang Cha
    • Jin-Hong Baek
    • Sang-Han Lee
  • View Affiliations

  • Published online on: Tuesday, February 1, 2011
  • Pages: 511-518
  • DOI: 10.3892/ijmm.2011.609

Abstract

For centuries, Aloe has been used as a herbal plant remedy against skin disorders, diabetes, and for its cardiac stimulatory activity. Here, we examined the gastroprotective effects of an Aloe vera polymer fraction (Avpf; molecular weight cut-off ≥50 kDa; 150 mg/kg body weight, p.o.) on an ethanol-induced gastric lesion mouse model. Mice pre-treated with Avpf had significantly fewer gastric lesions than their respective controls. To further examine the potential mechanism underlying this effect, we used reverse transcription-polymerase chain reaction to examine nitric oxide synthase and matrix metalloproteinase (MMP)mRNA expression on tissues from gastric lesions. Our results revealed that the mRNA expressions of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) were each reduced by ~50% in Avpf-treated mice vs. the controls, whereas, the mRNA expression levels of endothelial nitric oxide synthase remained unchanged. MMP-9, an index for gastric lesions, also alleviated the ethanol-treated gastric ulceration during Avpf treatment. These findings collectively suggest that Avpf significantly protects the gastric mucosa against ethanol-induced gastric damage, at least in part, by decreasing mRNA expression levels of not only iNOS and nNOS, but also MMP-9.
Journal Cover

April 2011
Volume 27 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Park, C., Nam, D., Son, H., Lee, S., Lee, H., Heo, J., Cha, T., Baek, J., & Lee, S. (2011). Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions. International Journal of Molecular Medicine, 27(4), 511-518.
MLA
Park, Nam, Son, Lee, Lee, Heo, Cha, Baek, and Sang-Han Lee. "Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions." International Journal of Molecular Medicine International Journal of Molecular Medicine 27.4 (2011): 511-518.
Chicago
Park, Nam, Son, Lee, Lee, Heo, Cha, Baek, and Sang-Han Lee. "Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions." International Journal of Molecular Medicine International Journal of Molecular Medicine 27 no. 4 (2011): 511-518.