Honokiol stimulates osteoblastogenesis by suppressing NF-κB activation

  • Authors:
    • Masayoshi Yamaguchi
    • Jack L. Arbiser
    • M. Neale Weitzmann
  • View Affiliations

  • Published online on: Wednesday, August 31, 2011
  • Pages: 1049-1053
  • DOI: 10.3892/ijmm.2011.786

Abstract

Magnolia officinalis, a component of Asian herbal teas, has long been employed in traditional Japanese and Chinese medicine to treat numerous maladies. Honokiol, a biphenolic compound, is now considered to be one of the major active ingredients of Magnolia extract, and is under intense investigation for its anti-angiogenic, anti-inflammatory, anti-tumor and neuroprotective properties. Biochemically, honokiol has been recognized to modulate the nuclear factor κ B (NF-κB) signal transduction pathway suggesting that it possesses anti-inflammatory properties. Inflammation is intimately associated with bone turnover and skeletal deterioration and consequently, anti-inflammatory drugs may hold significant promise as bone protective agents to stem bone loss in osteoporotic conditions. We and others have demonstrated that suppression of NF-κB blunts osteoclastic bone resorption, but promotes osteoblastic bone formation. Indeed previous studies have demonstrated the anti-osteoclastogenic effects of honokiol, however, activities on osteoblast differentiation and activity have yet to be investigated. In this study, we show that honokiol is a potent inducer of in vitro osteoblast differentiation by virtue of its capacity to suppress basal and tumor necrosis factor alpha (TNFα)-induced NF-κB activation and to alleviate the suppressive action of TNFα on bone morphogenetic protein (BMP)-2-induced Smad activation. Our data confirm that honokiol may have considerable promise as a dual anabolic/anti-catabolic agent for the amelioration of multiple osteoporotic diseases.
Journal Cover

December 2011
Volume 28 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
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APA
Yamaguchi, M., Yamaguchi, M., Arbiser, J., Arbiser, J., Weitzmann, M., & Weitzmann, M. (2011). Honokiol stimulates osteoblastogenesis by suppressing NF-κB activation. International Journal of Molecular Medicine, 28(6), 1049-1053.
MLA
Yamaguchi, Yamaguchi, Arbiser, Arbiser, Weitzmann, and M. Weitzmann. "Honokiol stimulates osteoblastogenesis by suppressing NF-κB activation." International Journal of Molecular Medicine International Journal of Molecular Medicine 28.6 (2011): 1049-1053.
Chicago
Yamaguchi, Yamaguchi, Arbiser, Arbiser, Weitzmann, and M. Weitzmann. "Honokiol stimulates osteoblastogenesis by suppressing NF-κB activation." International Journal of Molecular Medicine International Journal of Molecular Medicine 28 no. 6 (2011): 1049-1053.